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Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry
(2017-07-27)
Proteins are inherently dynamic. Virtually all of the processes that underlie biological activity, including binding partner recognition, catalysis and allostery among many others, require transient adoption of specific ...
Novel Kinetic Solution-Based Separation Approaches for Small Molecule Drug Discovery
(2017-07-27)
The modern pharmaceutical industry has achieved remarkable successes in medicinal chemistry. However, many diseases are incurable due to the difficulty of finding new drugs. De novo drug discovery contains two steps: the ...
Chemical and Physical Studies of Secondary Organic Aerosol Formed from Beta-pinene Photooxidation
(2017-07-27)
Atmospheric organic aerosols have a significant impact on climate and human health. However, our understanding of the physical and chemical properties of these aerosols is inadequate, thus their climate and health influences ...
Structural and Functional Studies of TraG From the F Plasmid and the Major Pilin From Coxiella Burnetii
(2017-07-26)
The Escherichia coli F-plasmid houses all genes necessary for the assembly of its conjugative machinery to facilitate successful DNA transfer. TraG is one of the largest proteins (102 kDa) encoded in the transfer (tra) ...
Structure-Function Studies of Scaffolding Proteins Involved in the Formation of Neuronal Connections: AIDA1 and CASKIN2
(2017-07-27)
Modular proteins serve assembly platforms and often actively regulate cellular signaling events. An intrinsic diversity of interaction modules, typical for scaffolding proteins, facilitates the organization of numerous ...
Synthesis of Primary Arylamines Using Bulky Palladium N-heterocyclic Carbene Precatalysts
(2017-07-27)
The reaction between aryl halides and ammonia was investigated using N-heterocyclic carbene (NHC) ligated palladium pre-catalysts. The use of NHCs is well documented for coupling of alkyl and arylamines, but there is little ...