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Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) ...
Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
The first part of this research focuses on developing efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered ...
One-Pot Synthesis of meta-Substituted Phenols via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling and Oxidation
We have developed a two-step synthesis of meta-substituted phenols in one pot, in good to excellent yield. A Pd2+ source is the catalyst for both steps of the synthesis, which includes a cross-coupling reaction between ...
Part I: Application of Pd-Peppsi Complexes in Regioselective Cross-Coupling and Natural Product Total Synthesis; Part II: Room Temperature, Additive-Free Carbon-Sulfur Coupling Using Novel NHC-Pd Complexes
The first part of this research is focused on the development of an efficient method for the regioselective Suzuki-Miyaura cross-coupling of allylboronic acid pinacol ester derivatives with aryl and heteroaryl halides using ...