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Part I: Palladium PEPPSI-IPENT CI, A Useful Catalyst for Challenging Amination Reactions Part II: Generation Of Benzynes in Flow Reactors followed by Subsequent Diels-Alder Reactions
The first part of this research focuses on developing efficient methods to address challenging Buchwald Hartwig amination reactions using Pd-NHC pre-catalysts. Specifically, we focused on: a) coupling of sterically hindered ...
Synthesis and Reactivity of Umpolung Reagents Through Transition Metal Catalysis
The cyclopropanol-derived palladium-homoenolates have previously been exploited as a unique class of cross-coupling partners in our group. The major advantage of using cyclopropanols as the cross-coupling partners is the ...
Iron-Doped Titanium Dioxide Nanomaterials: Synthesis, Characterization and Photodegradation Catalytic Behavior
Titanium dioxide (TiO2) is a very good material for various photocatalytic industrial applications because of its non-toxicity, high chemical stability, low cost and relatively good photoactivity. However, one of the most ...
Synthesis of Primary Arylamines Using Bulky Palladium N-heterocyclic Carbene Precatalysts
The reaction between aryl halides and ammonia was investigated using N-heterocyclic carbene (NHC) ligated palladium pre-catalysts. The use of NHCs is well documented for coupling of alkyl and arylamines, but there is little ...
Characterizing Conformational Dynamics and Catalytic Activity of Enzymes by Hydrogen-Deuterium Exchange Mass Spectrometry
Determining the conformational dynamics of enzymes as they undergo catalysis has been challenging for decades due to the short timescale and limitations of traditional analysis, including techniques such as CPMG 2D NMR and ...