Towards the understanding of palladium-catalyzed tandem cyclopropanol opening-direct arylation reactions

dc.contributor.advisor	Yousaf, Muhammad Naveed
dc.contributor.advisor	Potvin, Pierre G.
dc.creator	Dragisic, Bojan
dc.date.accessioned	2016-08-03T16:51:55Z
dc.date.available	2016-08-03T16:51:55Z
dc.date.copyright	2012-12
dc.degree.discipline	Chemistry
dc.degree.level	Master's
dc.degree.name	MSc - Master of Science
dc.description.abstract	Insight into the stereoelectronic requirements for intramolecular direct arylation reactions is presented. Substrates were designed and synthesized with the goal of elucidating the steric, electronic, and conformational requirements for the concerted metalation-deprotonation process in intramolecular direct arylation reactions. Poor conversions and yields were obtained with rotationally-constrained systems not possessing electron-withdrawing, or activating, groups on the aryl ring. Systems containing both activated and unactivated protons participating in CMD showed full selectivity for the activated protons.
dc.identifier.uri	http://hdl.handle.net/10315/31714
dc.rights	Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subject.keywords	Arylation
dc.subject.keywords	Intramolecular direct arylation reactions
dc.subject.keywords	Stereoelectronic requirements
dc.subject.keywords	Metalation-deprotonation process
dc.title	Towards the understanding of palladium-catalyzed tandem cyclopropanol opening-direct arylation reactions
dc.type	Electronic Thesis or Dissertation

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