A High-Speed and Low-Noise Nanopore Amplifier and Event Detector

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dc.contributor.advisorMagierowski, Sebastian
dc.contributor.authorHuang, Yiyun
dc.date.accessioned2024-11-07T14:27:12Z
dc.date.available2024-11-07T14:27:12Z
dc.date.copyright2015-12-08
dc.date.issued2024-11-07
dc.date.updated2024-11-07T14:27:11Z
dc.degree.disciplineComputer Engineering
dc.degree.levelMaster's
dc.degree.nameMASc - Master of Applied Science
dc.description.abstractThis thesis focus on the design of an improved-accuracy algorithm for real-time nanopore-based signal detection (e.g. base calling) and high-speed nanopore signal measurement circuits with low-noise. First, the proposed approach is based on the cumulative sum technique but employs a decision-directed policy coupled with a post-decision correction mechanism to achieve at least a 10× accuracy improvement over a previously reported method. As a result the new technique can better accommodate high-speed embedded nanopore measurement applications such as DNA sequencing. For the circuit design, we apply the CMOS technology since the nanopore-based molecular sensing affords a close coupling between DNA sequencing and semiconductor signal processing. The key analog front-end components of such an ASIC are described herein. In particular, the design of a 3-MHz 130-nm CMOS front-end with reduced area, 2× reduction in power, and 25% noise improvement compare with state of-the-art designs.
dc.identifier.urihttps://hdl.handle.net/10315/42539
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectElectrical engineering
dc.subjectComputer engineering
dc.subject.keywordsNanopore sequencing
dc.subject.keywordsReal-time detection
dc.subject.keywordsCUSUM
dc.subject.keywordsTransimpedance amplifier
dc.subject.keywordsCMOS
dc.titleA High-Speed and Low-Noise Nanopore Amplifier and Event Detector
dc.typeElectronic Thesis or Dissertation

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