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Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
Obesity is a key factor contributing to the “metabolic syndrome” which increases the risk for type 2 diabetes, cardiovascular disease and liver complications. In obese conditions, lipotoxicity is a serious concern as the ...
Investigation of Mechanisms Responsible for Myocyte Cell Death in Metabolic Syndrome
The aim of study is to investigate the mechanism involved in myocyte cell death in metabolic syndrome. Specific metabolic syndrome conditions focused on in this research are iron overload and hyperglycemia. Both in skeletal ...
The Effects of LCN2 and Iron on Cardiac Remodeling and the Impact on Cardiac Function
Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) is a proinflammatory factor which is elevated in obese individuals. It has also been implicated in the pathogenesis of heart failure and as ...