Biology
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Characterization of Nucleosomes Containing Specific Forms of the Histone Variant H2A.Z
(2019-11-22)H2A.Z is a highly conserved histone variant that replaces canonical histone H2A at specific loci to regulate diverse nuclear processes. Amongst these, the role of H2A.Z in transcriptional regulation is of particular interest ... -
Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio)
(2019-11-22)Iron (Fe) is an essential trace metal for development; however, its level in the body must be maintained within physiological range. In the present study, the effects of dietary Fe on growth, trace metal homeostasis, and ... -
Transendothelial Movement of Adiponectin in Diabetic Vasculature
(2019-11-22)Adiponectin is one of the most abundant circulatory hormone that plays an important role on homeostasis of glucose and lipid, oxidative stress, and inflammation by enhancing insulin sensitivity. It is highly implicated to ... -
Using Zebrafish as a Model for Investigating the Neuropathophysiology of Iron Overload During Development
(2019-11-22)In this research, we used larval zebrafish (Danio rerio) to examine the effects of iron (Fe) exposure on neurophysiological performance and oxidative-stress responses during development. Our findings demonstrated that ... -
Functional Elucidation and Characterization of GPA2/GPB5 and Its Receptor LGR1 in the Mosquito, Aedes Aegypti
(2019-11-22)Glycoprotein hormones govern key aspects of physiology like reproduction, growth and development as well as metabolism in vertebrates. In 2002, a novel glycoprotein hormone formed by the heterodimeric interactions of GPA2 ... -
Determining the Genes for Distyly in Turnera
(2019-11-22)Heterostyly promotes outbreeding and reduces pollen wastage. Distylous species have two mating types: L-morph and S-morph plants, which are genetically determined by the S-locus. It was hypothesized that the S-locus carries ... -
Role of Fra-2/AP-1 in Myogenic Progenitor Cells
(2019-11-22)Components of AP-1 have dynamic expression profiles during myogenesis in C2C12 cells, the expression profile of AP-1 is different among proliferative myoblasts, differentiating myoblasts, differentiated myotubes and reserve ... -
Toward A High Throughput Label-Free Platform for Monitoring Interaction Between Cells and Superparamagnetic Iron Oxide Nanoparticles
(2019-11-22)This thesis focuses on cytotoxicity examination of superparamagnetic iron oxide nanoparticles (SPIONs) using different methods, including impedance spectroscopy. Despite the significant advances in adapting various biological ... -
Using Light-Level Geolocation to Investigate the Carry-Over Effects of Long-Distance Migration on the Reproductive Success of Dunlin (Calidris Alpina Hudsonia)
(2019-11-22)Avian migration strategies can have lasting effects on individual fitness in subsequent seasons. These carry-over effects are difficult to study in migratory species because of the geographical separation between breeding ... -
AP-1 Proteins Regulate Autophagy in Skeletal Muscle Progenitor Cells
(2019-11-22)Autophagy has been observed to be a key regulator in myogenesis, maintenance of quiescence in satellite cells (SC) and regenerative capacity of skeletal muscle. Activator protein-1 (AP-1) transcription factors have been ... -
Effects of Climate Change on Lake Ice Freeze Up Across the Northern Hemisphere: Historical Patterns and Future Predictions
(2019-07-02)Shifts in freeze up dates signal climatic change. We examined nine lakes in the Great Lakes region to forecast freeze up dates into the future. We also examined 75 lakes around the Northern Hemisphere to understand how and ... -
The Role of a -Catenin - FMRP Complex In Skeletal Muscle
(2019-07-02)Skeletal muscle consists of multinucleated myofibers which generate contractile force and regulate glucose levels in the human body. Over time, skeletal muscle can become damaged and therefore requires a robust capacity ... -
Investigating Changes in Lake Ice Breakup Under Current and Future Climate Change
(2019-07-02)Changes in climate profoundly influence the timing of lake ice breakup. We assessed: 1) potential future changes in lake ice breakup date in the Great Lakes Region and 2) historical linear changes and shifts in ice breakup ... -
Measuring the exposure of Songbird Nestlings to Neonicotinoids in Natural and Agricultural Nest Sites
(2019-07-02)Neonicotinoid insecticides such as imidacloprid (IMI) have been under scrutiny for their damage on non-target invertebrates. However, recent literature suggests that grassland birds are experiencing population declines ... -
Investigating Interaction Partners Of Yeast UBPS and Human USP7 Deubiquitinases
(2019-07-02)Ubiquitin-specific proteases (USPs; Ubps) are the most abundant family of deubiquitinating enzymes. Their involvement in various cellular processes, which are implicated in development and diseases such as cancer, have ... -
Investigating the Effects of Sumoylation on the Yeast General Transcription Factor TFIIF
(2019-03-05)Sumoylation is a post-translational modification that regulates numerous cellular processes including gene expression. We find that among the general transcription factors of RNA Polymerase II (RNAPII) in budding yeast, ... -
The Role of miR-590-3p in Regulating Human Epithelial Ovarian Cancer Development
(2019-03-05)Epithelial ovarian cancer (EOC) has the highest mortality rate among all gynecological malignancies. Early detection and intervention remain key to patient prognosis fueling the search for reliable biomarkers. MicroRNAs ... -
Pollinator-Mediated Interactions of Foundation Plants in the Mojave Desert
(2019-03-05)Pollination facilitation is an indirect interaction whereby one plant species positively influences the reproductive success of another plant species through pollinators. First, we conducted a systematic review of the ... -
Elucidating the Mechanisms Surrounding H2A.X Monoubiquitylation Marks in the DNA Damage Response Pathway
(2019-03-05)In response to DNA double-strand breaks (DSBs), H2A.X undergoes three post-translational modifications (PTMs) reported to be important for DSB signaling: phosphorylation at serine 139, monoubiquitylation at lysines 118/119 ... -
Searching for the Genetic Basis of Hygienic Behavior and Overwintering in the Honeybee (Apis mellifera)
(2019-03-05)The recent decline in honeybee populations can be mitigated through genomics and marker-assisted selection. The current techniques, such as chemical treatment to prevent disease, are only short-term solutions. The ability ...
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