Biology
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Barrier Properties and Molecular Physiology of Fish Gill Epithelia and Gill Epithelium Models
(2020-11-13)The fish gill epithelium interfaces directly with surrounding water and participates in numerous physiological processes. However, the barrier properties of the fish gill epithelium have been largely overlooked until recent ... -
Exercise Dose Dependent Atrial Remodelling and Atrial Fibrillation
(2020-11-13)The dependence of atrial fibrillation (AF) on exercise dose is U shaped. To assess the physiological basis for this relationship, we swam 3 groups of CD1 mice at variable daily durations (120, 180 and 240 minutes per day) ... -
Circadian Rhythm in Intrinsic Heart Rate
(2020-11-13)Heart rate (HR) as well as adverse cardiac events (i.e. myocardial infarction, arrhythmias, stroke, and sudden cardiac death) show circadian patterns. Circadian HR fluctuations are traditionally thought to be controlled ... -
Analysis of Spatial Learning in Honeybee Foragers Using the Food Search Box Assay
(2020-11-13)Given the under-representation of genetic analyses of spatial learning in honeybee literature, I designed an experiment to investigate gene expression profiles associated with spatial learning. The experimental design ... -
Hippocampal and Neocortical Dynamics During Long-term Memory in Macaques
(2020-11-13)Memory is one of the most important faculties of the mind. Memory keeps a record of our experiences which enriches our sense of self, enables us to make adaptive decisions in the present and informed plans for the future. ... -
Carry-Over Effects of Overwinter Climate and Habitat Productivity on Spring Arrival of Migratory Songbirds at a Northern Stopover Site
(2020-11-13)Reduced rainfall in tropical regions may impact the ability of temperate-breeding songbirds to prepare for and execute their spring migration. I used 34 years of bird banding data from Ontario to test for the presence of ... -
Examining the Role of Phosphorylation in the Gain and Loss of the Elasticity of the Tethers that Connect Separating Anaphase Chromosomes in Crane-Fly Spermatocytes
(2020-11-13)This thesis deals with elasticity of the tethers that connect anaphase chromosomes in crane-fly spermatocytes. Chromosomes move backwards after reaching the poles when Calyculin A (CalA), an inhibitor of protein phosphatases ... -
Assessing the Effects of Temperature, Feeding Status, and the Microbiome on the Maximal Activities of Several Enzymes Important to Energy Production and Ammonia Detoxification in the Intestines of Teleost Fish
(2020-11-13)This thesis examined the effects of temperature, feeding status, and the microbiome on the maximal activities of several enzymes important to energy production and ammonia (NH3) detoxification in the intestines of three ... -
Effects of Exposure to CdSe/ZnS Quantum Dots on the Neurophysiological Performance of Developing Zebrafish
(2020-08-11)This research investigated the effects of exposure to sublethal concentrations of CdSe/ZnS quantum dots on the neurophysiological performance of larval zebrafish. Whole body metal content, physiological conditions, and ... -
Chironomid Autoecology of the Past and Present, and a Causal Analysis of Recreational Shoreline Developments on Hypolimnetic Oxygen in Algonquin Park Lakes
(2020-08-11)Recreational cottages continue to be leased within Algonquin Park despite inadequate assessments of cottage impacts on lake water quality and ecosystem integrity. Cottages can increase phosphorus export to lakes, resulting ... -
Effects of Spatial and Temporal Variation in Resource Availability on the Growth Rates and Survival of Dunlin (Calidris Alpina Hudsonia) Chicks
(2020-08-11)Long-distant migrants nesting in the Arctic experience condensed breeding seasons and shorter periods of high arthropod availability due to climate change. Shorebirds have precocial chicks which may compensate for food ... -
The Effect of Misoprostol on Neuronal Stem Cell Migration and Differentiation
(2020-08-11)Misoprostol is a drug commonly used for medical termination of pregnancy, and improper use has been linked to neurodevelopmental disorders such as Moebius syndrome and Autism Spectrum Disorder (ASD). It is an analog of ... -
Regulation of Yeast Transcription Factors Sko1 and Cst6 by Sumoylation
(2020-08-11)Sumoylation is a post-translational modification that plays an essential role in cellular processes, including transcriptional regulation. Transcription factors represent one of the largest groups of proteins that are ... -
Functional Characterization of Pyrokinins and their Receptors in the Adult Mosquito, Aedes aegypti
(2020-08-11)The mosquito Aedes aegypti is a common disease vector that continues to cause devastating harm to human populations. Mosquitoes owe much of their success to their excretory system, comprised of the Malpighian tubules and ... -
Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
(2020-08-11)Unbalanced energy intake over expenditure causes obesity, and the prevalence and incidences of obesity have increased over last decades. People with obesity have a cluster of metabolic co-morbidities called metabolic ... -
Foraging Ecology and Contaminant Burdens of Ringed Seals (Pusa hispida) in the Central Canadian Arctic
(2020-05-11)Increasing temperatures have led to declines in the extent of Arctic sea ice. Due to their reliance on sea ice and central position within Arctic marine food webs, ringed seals (Pusa hispida) are particularly vulnerable ... -
Expression and Regulatory Mechanisms of SNAP25 and Syntaxin 1A in H9c2 Cells
(2020-05-11)Two SNARE proteins, SNAP25 and STX1A, are widely expressed in neurons and neuroendocrine cells, and more recently, shown to be expressed in the heart, but their underlying mechanisms remain unknown. This study examined the ... -
Characterizing the Role of Syntaxin 1A in the Heart
(2020-05-11)The SNARE protein, STX1A, is expressed in various tissues. However, the role of STX1A in the heart remains unclear. Using a cardiac-specific STX1A knockout mouse model, this thesis explores the potential role of STX1A in ... -
Characterization of a Highly Dynamic Region in Trag from the F Plasmid
(2020-05-11)The Escherichia coli F plasmid is representative of conjugative type IV secretion system for the transmission of mobile DNA elements in bacteria, a contributor to widespread antibiotic resistance. The TraG protein of this ... -
Role of UV90 Gene in the FRQ-Less Oscillator of the Neurospora Crassa Circadian System
(2020-05-11)Circadian rhythms are found in all domains of life and control many physiological processes. Transcription/translation feedback loops (TTFLs) are important molecular mechanisms in circadian systems. In the model eukaryote ...
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