Biology
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Chironomid Autoecology of the Past and Present, and a Causal Analysis of Recreational Shoreline Developments on Hypolimnetic Oxygen in Algonquin Park Lakes
(2020-08-11)Recreational cottages continue to be leased within Algonquin Park despite inadequate assessments of cottage impacts on lake water quality and ecosystem integrity. Cottages can increase phosphorus export to lakes, resulting ... -
The Effect of Misoprostol on Neuronal Stem Cell Migration and Differentiation
(2020-08-11)Misoprostol is a drug commonly used for medical termination of pregnancy, and improper use has been linked to neurodevelopmental disorders such as Moebius syndrome and Autism Spectrum Disorder (ASD). It is an analog of ... -
Regulation of Yeast Transcription Factors Sko1 and Cst6 by Sumoylation
(2020-08-11)Sumoylation is a post-translational modification that plays an essential role in cellular processes, including transcriptional regulation. Transcription factors represent one of the largest groups of proteins that are ... -
Functional Characterization of Pyrokinins and their Receptors in the Adult Mosquito, Aedes aegypti
(2020-08-11)The mosquito Aedes aegypti is a common disease vector that continues to cause devastating harm to human populations. Mosquitoes owe much of their success to their excretory system, comprised of the Malpighian tubules and ... -
Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
(2020-08-11)Unbalanced energy intake over expenditure causes obesity, and the prevalence and incidences of obesity have increased over last decades. People with obesity have a cluster of metabolic co-morbidities called metabolic ... -
Foraging Ecology and Contaminant Burdens of Ringed Seals (Pusa hispida) in the Central Canadian Arctic
(2020-05-11)Increasing temperatures have led to declines in the extent of Arctic sea ice. Due to their reliance on sea ice and central position within Arctic marine food webs, ringed seals (Pusa hispida) are particularly vulnerable ... -
Expression and Regulatory Mechanisms of SNAP25 and Syntaxin 1A in H9c2 Cells
(2020-05-11)Two SNARE proteins, SNAP25 and STX1A, are widely expressed in neurons and neuroendocrine cells, and more recently, shown to be expressed in the heart, but their underlying mechanisms remain unknown. This study examined the ... -
Characterizing the Role of Syntaxin 1A in the Heart
(2020-05-11)The SNARE protein, STX1A, is expressed in various tissues. However, the role of STX1A in the heart remains unclear. Using a cardiac-specific STX1A knockout mouse model, this thesis explores the potential role of STX1A in ... -
Characterization of a Highly Dynamic Region in Trag from the F Plasmid
(2020-05-11)The Escherichia coli F plasmid is representative of conjugative type IV secretion system for the transmission of mobile DNA elements in bacteria, a contributor to widespread antibiotic resistance. The TraG protein of this ... -
Role of UV90 Gene in the FRQ-Less Oscillator of the Neurospora Crassa Circadian System
(2020-05-11)Circadian rhythms are found in all domains of life and control many physiological processes. Transcription/translation feedback loops (TTFLs) are important molecular mechanisms in circadian systems. In the model eukaryote ... -
Negative Selection in Social Insects
(2020-05-11)Eusociality, characterized by cooperative brood care, and reproductive division of labor, evolved independently in insects. The evolution of eusociality has been hypothesized to lead to differences in the extent of both ... -
Investigating the Anti-Tumor Effects of Two Novel B-Catenin Inhibitors in Ovarian Cancer Cells
(2020-05-11)Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The development of chemoresistance and relapse becomes a major challenge in treating ovarian cancer. The Wnt/-catenin pathway, which plays a critical ... -
Investigating Changes in Chlorophyll a and Other Water Chemistry Variables in Response to Global Environmental Change
(2020-05-11)Changes in water quality are influenced by climate change and other anthropogenic stressors. We 1) assessed changes in water quality in lakes in the Laurentian Great Lakes region, and 2) compiled water quality data for ... -
Transcriptional Regulation of Pokeweed Antiviral Protein
(2020-05-11)Phytolacca americana (American pokeweed) expresses pokeweed antiviral protein (PAP), a ribosome-inactivating protein (RIP) thought to function in defence. Several PAP isoforms are differentially responsive to jasmonic acid ... -
The Impact of Freshwater Salinization on the Osmoregulatory Physiology of Mayfly Nymphs (Hexagenia Rigida)
(2020-05-11)Freshwater (FW) salinization (the accumulation of salt in FW), is an environmental issue which threatens the health of FW ecosystems worldwide. This study used FW nymphs of the mayfly Hexagenia rigida, to provide a first ... -
Eye-Head-Hand Coordination During Visually Guided Reaches in Head-Unrestrained Macaques
(2020-05-11)Our goal was to determine if reaching influences eye-head coordination (and vice versa) in Rhesus macaques. Eye, head, and hand motion were recorded in two animals using search coil and touch screen technology, respectively. ... -
Investigating Indirect Anthropogenic Effects on Spatial Variation in Nest Predation Risk and Shorebird Nest Success in Churchill, Manitoba
(2020-05-11)Nest predation risk increases at lower latitudes, and some shorebirds nesting at the southernmost limits of their ranges in Churchill, Manitoba tend to experience lower nest success than those at other Arctic sites. This ... -
Characterization of Defense-Associated Gene Expression in Phytolacca Americana Using Novel Transcriptomic and Genomic Resources
(2020-05-11)Phytolacca americana (pokeweed) is a non-model plant with agriculturally relevant characteristics, being a heavy metal hyperaccumulator resistant to virus infection. Pokeweed synthesizes pokeweed antiviral protein (PAP), ... -
Systematics and Biogeography of Colletinae with Revisionary Studies of the Species of Colletes Latreille (Hymenoptera:Colletidae: Colletinae) from Chile and Eastern South America
(2020-05-11)Colletinae (Hymenoptera: Colletidae) includes c. 545 species, the majority of which (c. 520 species) belong to Colletes Latreille. The generic placement of the other 25 species has been controversial, with the number of ... -
Iron Overload Reduces Adiponectin Receptor-1 Expression via a ROS/FOXO1-Dependent Mechanism Leading to Adiponectin Resistance in Skeletal Muscle Cells
(2020-05-11)Iron overload (IO) is a common yet underappreciated observation in metabolic syndrome (MetS) patients. With the prevalence of MetS continuing to rise, it is of utmost importance to further elucidate mechanisms leading to ...
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