Biology
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Foraging Ecology and Contaminant Burdens of Ringed Seals (Pusa hispida) in the Central Canadian Arctic
(2020-05-11)Increasing temperatures have led to declines in the extent of Arctic sea ice. Due to their reliance on sea ice and central position within Arctic marine food webs, ringed seals (Pusa hispida) are particularly vulnerable ... -
Expression and Regulatory Mechanisms of SNAP25 and Syntaxin 1A in H9c2 Cells
(2020-05-11)Two SNARE proteins, SNAP25 and STX1A, are widely expressed in neurons and neuroendocrine cells, and more recently, shown to be expressed in the heart, but their underlying mechanisms remain unknown. This study examined the ... -
Characterizing the Role of Syntaxin 1A in the Heart
(2020-05-11)The SNARE protein, STX1A, is expressed in various tissues. However, the role of STX1A in the heart remains unclear. Using a cardiac-specific STX1A knockout mouse model, this thesis explores the potential role of STX1A in ... -
Characterization of a Highly Dynamic Region in Trag from the F Plasmid
(2020-05-11)The Escherichia coli F plasmid is representative of conjugative type IV secretion system for the transmission of mobile DNA elements in bacteria, a contributor to widespread antibiotic resistance. The TraG protein of this ... -
Role of UV90 Gene in the FRQ-Less Oscillator of the Neurospora Crassa Circadian System
(2020-05-11)Circadian rhythms are found in all domains of life and control many physiological processes. Transcription/translation feedback loops (TTFLs) are important molecular mechanisms in circadian systems. In the model eukaryote ... -
Negative Selection in Social Insects
(2020-05-11)Eusociality, characterized by cooperative brood care, and reproductive division of labor, evolved independently in insects. The evolution of eusociality has been hypothesized to lead to differences in the extent of both ... -
Investigating the Anti-Tumor Effects of Two Novel B-Catenin Inhibitors in Ovarian Cancer Cells
(2020-05-11)Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The development of chemoresistance and relapse becomes a major challenge in treating ovarian cancer. The Wnt/-catenin pathway, which plays a critical ... -
Investigating Changes in Chlorophyll a and Other Water Chemistry Variables in Response to Global Environmental Change
(2020-05-11)Changes in water quality are influenced by climate change and other anthropogenic stressors. We 1) assessed changes in water quality in lakes in the Laurentian Great Lakes region, and 2) compiled water quality data for ... -
Transcriptional Regulation of Pokeweed Antiviral Protein
(2020-05-11)Phytolacca americana (American pokeweed) expresses pokeweed antiviral protein (PAP), a ribosome-inactivating protein (RIP) thought to function in defence. Several PAP isoforms are differentially responsive to jasmonic acid ... -
The Impact of Freshwater Salinization on the Osmoregulatory Physiology of Mayfly Nymphs (Hexagenia Rigida)
(2020-05-11)Freshwater (FW) salinization (the accumulation of salt in FW), is an environmental issue which threatens the health of FW ecosystems worldwide. This study used FW nymphs of the mayfly Hexagenia rigida, to provide a first ... -
Eye-Head-Hand Coordination During Visually Guided Reaches in Head-Unrestrained Macaques
(2020-05-11)Our goal was to determine if reaching influences eye-head coordination (and vice versa) in Rhesus macaques. Eye, head, and hand motion were recorded in two animals using search coil and touch screen technology, respectively. ... -
Investigating Indirect Anthropogenic Effects on Spatial Variation in Nest Predation Risk and Shorebird Nest Success in Churchill, Manitoba
(2020-05-11)Nest predation risk increases at lower latitudes, and some shorebirds nesting at the southernmost limits of their ranges in Churchill, Manitoba tend to experience lower nest success than those at other Arctic sites. This ... -
Characterization of Defense-Associated Gene Expression in Phytolacca Americana Using Novel Transcriptomic and Genomic Resources
(2020-05-11)Phytolacca americana (pokeweed) is a non-model plant with agriculturally relevant characteristics, being a heavy metal hyperaccumulator resistant to virus infection. Pokeweed synthesizes pokeweed antiviral protein (PAP), ... -
Systematics and Biogeography of Colletinae with Revisionary Studies of the Species of Colletes Latreille (Hymenoptera:Colletidae: Colletinae) from Chile and Eastern South America
(2020-05-11)Colletinae (Hymenoptera: Colletidae) includes c. 545 species, the majority of which (c. 520 species) belong to Colletes Latreille. The generic placement of the other 25 species has been controversial, with the number of ... -
Iron Overload Reduces Adiponectin Receptor-1 Expression via a ROS/FOXO1-Dependent Mechanism Leading to Adiponectin Resistance in Skeletal Muscle Cells
(2020-05-11)Iron overload (IO) is a common yet underappreciated observation in metabolic syndrome (MetS) patients. With the prevalence of MetS continuing to rise, it is of utmost importance to further elucidate mechanisms leading to ... -
Impacts of Climate Change and Multiple Stressors on Water Levels and Phytoplankton in Small Temperate Lakes Within the Great Lakes Region Over Three Decades
(2020-05-11)Changes in climate influence water quantity and water quality through hydrological processes, thermal regimes, and ice phenology. This thesis investigates the impacts of climate change and additional anthropogenic stressors ... -
Characterization of Nucleosomes Containing Specific Forms of the Histone Variant H2A.Z
(2019-11-22)H2A.Z is a highly conserved histone variant that replaces canonical histone H2A at specific loci to regulate diverse nuclear processes. Amongst these, the role of H2A.Z in transcriptional regulation is of particular interest ... -
Influence of Dietary Iron Exposure on the Physiological Regulation of Iron and other Trace Metals During Development in Zebrafish (Danio Rerio)
(2019-11-22)Iron (Fe) is an essential trace metal for development; however, its level in the body must be maintained within physiological range. In the present study, the effects of dietary Fe on growth, trace metal homeostasis, and ... -
Transendothelial Movement of Adiponectin in Diabetic Vasculature
(2019-11-22)Adiponectin is one of the most abundant circulatory hormone that plays an important role on homeostasis of glucose and lipid, oxidative stress, and inflammation by enhancing insulin sensitivity. It is highly implicated to ... -
Using Zebrafish as a Model for Investigating the Neuropathophysiology of Iron Overload During Development
(2019-11-22)In this research, we used larval zebrafish (Danio rerio) to examine the effects of iron (Fe) exposure on neurophysiological performance and oxidative-stress responses during development. Our findings demonstrated that ...
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