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Part I: Crystallization of A Type IV Pilin from Pseudomonas Aeruginosa. Part II: Characterization of a Peptidyl-Prolyl-Cis,Trans-Isomerase Through X-Ray Crystallography 

Yaseen, Ayat (2018-05-28)
Within a host, pathogenic bacteria employ several mechanisms that enhance their survival and motility. These mechanisms include their ability to adhere, replicate (in order to avoid eradication), and secretion of virulent ...
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Front-End Methods For Enhancing the Analytical Power of Mass Spectrometry 

Liuni, Peter Paul (2016-09-20)
The analytical power and versatility of mass spectrometry can be enhanced by adding front-end devices, which provide additional functionality before, during or immediately after ElectroSpray Ionization (ESI). Such devices ...
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The Cocaine-Binding Aptamer: A Thermodynamic and Structural Overview of Specific and Non-Specific Binding Interactions 

Reinstein, Oren (2016-09-20)
Isothermal Titration Calorimetry (ITC) studies were conducted wherein variances in the heat capacity of binding (Cp) among variants of the cocaine-binding aptamer were suggestive of two distinct binding mechanisms. Aptamer ...
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Studies of Protein Function by Liquid Chromatography-Mass Spectrometry 

Declan Williams, Gwillym (2015-01-26)
Complete genomes of many organisms have been recorded using high throughput nucleic acid sequencing; however the intricate functions of the gene products remain largely undiscovered. As the most prominent technology for ...
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Characterization of Function and Role of FMTA in Staphylococcus Aureus 

Rahman, Muhammad Masfiqur (2015-08-28)
Staphylococcus aureus is one of the major reasons for infectious mortality and morbidity. Due to extensive use of antibiotics, S. aureus has acquired resistance to almost all antibiotics. FmtA is one of the additional ...
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Obtaining Structural Insights on Bacterial Protein Complexes Using Time-Resolved Hydrogen-Deuterium Exchange Mass Spectrometry 

Lento, Cristina (2015-12-16)
Persistent infections by Pseudomonas aeruginosa are initiated by interaction of a type IV pilus (T4P) with receptors on the mucosal cells of susceptible hosts. Here, we examine the structural changes occurring between the ...
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Measuring the Dynamics and Kinetics of OXA-58, a Class D Abeta-Lactamase from Acinetobacter Baumannii 

Gill, Preet Kamal Singh; Wilson, Derek J. (2015-12-16)
OXA-58 is a β-lactamase enzyme that bacteria Acinetobacter baumannii employ as their chief defense mechanism against β-lactam antibiotic treatment. The catalytic activity of OXA-58 and its mutants was monitored as they ...
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Structural Studies of the Receiver Domain of LytR from Staphylococcus Aureus and Interaction Studies of TraW and TrbC from the F Plasmid of Escherichia Coli 

Shala, Agnesa (2015-01-26)
The emergence of the multi-drug resistant bacteria and the evolutionary spread of the antibiotic resistance genes have become a great concern to human health. Bacteria use various systems in combination or alone in response ...
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Biomedical Characterization of the WalKR and the LytSR Two Component System From Staphylococcus Aureus 

Patel, Kevin Hasmukhlal (2015-08-28)
Staphylococcus aureus is a major gram-positive pathogen, because of its remarkable capacity to develop resistance against different antimicrobial agents. It has been shown that in S. aureus two component systems (TCS) ...
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Characterizing Protein Dynamics of Protein-Ligand Interactions by Hydrogen-Deuterium Exchange Mass Spectrometry 

Resetca, Diana (2015-01-26)
The study of protein-ligand and protein-protein interactions is of paramount importance to the understanding of their biological function. Whereas this area of research has been largely dominated by conventional structural ...
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AuthorDeclan Williams, Gwillym (1)Elahipanah, Sina (1)Gill, Preet Kamal Singh (1)Hassan, Muhammad Murtaza (1)Huang, Xiaojing (1)Lento, Cristina (1)Liuni, Peter Paul (1)Nouchikian, Lucienne (1)Patel, Kevin Hasmukhlal (1)Rahman, Muhammad Masfiqur (1)... View MoreSubject
Biochemistry (17)
Chemistry (7)HDX (4)Biology (3)mass spectrometry (3)DNA (2)HDX-MS (2)Isothermal titration calorimetry (2)Mass spectrometry (2)MS (2)... View MoreDate Issued2015 (7)2018 (3)2019 (3)2016 (2)2020 (1)2022 (1)Has File(s)Yes (17)

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.

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