Effects of the Brain Derived Neurotrophic Factor Val66met Polymorphism on the Structural and Functional Architecture of the Human Brain

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dc.contributor.advisorStevens, Dale
dc.contributor.authorAlba Suarez, Vicente Alejandro
dc.date.accessioned2022-12-14T16:38:20Z
dc.date.available2022-12-14T16:38:20Z
dc.date.copyright2022-08-24
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:38:20Z
dc.degree.disciplinePsychology(Functional Area: Brain, Behaviour & Cognitive Sciences
dc.degree.levelMaster's
dc.degree.nameMA - Master of Arts
dc.description.abstractBrain Derived Neurotrophic Factor (BDNF) is an important neurotrophin enabling synaptogenesis at the dendrites of neurons. Several studies have implicated the Val66Met single nucleotide polymorphism of the BDNF gene as a factor affecting cortical thickness and resting-state functional connectivity (RSFC) of the human brain. In this thesis, I investigated the effects of Val66Met on cortical thickness and RSFC among individual cortical regions and at the level of large-scale functional networks in all genotype groups (Val/Val, Val/Met, Met/Met, and Met carriers). Cutting-edge techniques were used to individually localize anatomical and functional brain regions in a large sample of healthy young adults from the Human Connectome Project. A comprehensive series of analyses revealed no significant group differences in cortical thickness or RSFC across the brain. These results suggest that, contrary to previous reports, the Met allele does not confer differences in structural or functional integrity of the healthy young adult brain.
dc.identifier.urihttp://hdl.handle.net/10315/40743
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectNeurosciences
dc.subjectGenetics
dc.subject.keywordsBrain derived neurotrophic factor (BDNF)
dc.subject.keywordsResting-state
dc.subject.keywordsFunctional connectivity
dc.subject.keywordsCortical thickness
dc.subject.keywordsfMRI
dc.subject.keywordsGene
dc.subject.keywordsHealthy young adults
dc.titleEffects of the Brain Derived Neurotrophic Factor Val66met Polymorphism on the Structural and Functional Architecture of the Human Brain
dc.typeElectronic Thesis or Dissertation

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