Comparison of Autonomic and Cardiovascular Dysfunction to Cognitive Decline in Persons with Type 2 Diabetes

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dc.contributor.advisorEdgell, Heather
dc.contributor.authorRamraj, Olivia
dc.date.accessioned2023-12-08T14:37:02Z
dc.date.available2023-12-08T14:37:02Z
dc.date.issued2023-12-08
dc.date.updated2023-12-08T14:37:02Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis thesis investigated the relationship between autonomic and cardiovascular dysfunction and cognitive decline in type 2 diabetes. Autonomic indices such as heart rate, blood pressure, pulse wave velocity and cardiac output response to exercise were measured as well as flow mediated dilation and pulse wave reactive hyperemia index. Global cognitive function, executive function and verbal learning tests were administered. Linear regression and correlations were performed between cognitive scores, and vascular and autonomic parameters. Microvascular function was inversely related to verbal learning (n=10, r=-0.86, p=0.0013) and executive function (n=11, r=-0.64, p=0.033). Resting cardiac output was associated with verbal learning (n=8, r=0.77, p=0.025). Heart rate during exercise was associated with global function (n=9, r=0.84, p=0.0020). The second minute of heart rate recovery was inversely related to global function (n=9, r=-0.71, p=0.030) and verbal learning (n=8, -0.71, p=0.037). Overall, hypoperfusion and reduced parasympathetic function were predictors of cognitive decline in type 2 diabetes.
dc.identifier.urihttps://hdl.handle.net/10315/41700
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectPhysiology
dc.subjectHealth sciences
dc.subject.keywordsKinesiology
dc.subject.keywordsCardiovascular
dc.subject.keywordsVascular
dc.subject.keywordsMicrovascular
dc.subject.keywordsEndothelial function
dc.subject.keywordsHealth
dc.subject.keywordsDiabetes
dc.subject.keywordsType 2 diabetes
dc.subject.keywordsCognitive function
dc.subject.keywordsCognitive decline
dc.subject.keywordsAutonomic function
dc.subject.keywordsAutonomic dysfunction
dc.subject.keywordsFlow mediated dilation
dc.subject.keywordsPulse wave velocity
dc.subject.keywordsShear rate
dc.subject.keywordsCardiac output
dc.subject.keywordsReactive hyperemia
dc.subject.keywordsHeart rate
dc.subject.keywordsHeart rate recovery
dc.subject.keywordsResting heart rate
dc.subject.keywordsBlood pressure
dc.subject.keywordsMean arterial pressure
dc.subject.keywordsHeart rate variability
dc.subject.keywordsArterial stiffness
dc.subject.keywordsEndothelial dysfunction
dc.subject.keywordsExecutive function
dc.subject.keywordsVerbal learning
dc.subject.keywordsPhysiology
dc.subject.keywordsNon-invasive
dc.subject.keywordsResponse to exercise
dc.subject.keywordsIsometric hand grip
dc.subject.keywordsSympathetic nervous system
dc.subject.keywordsSympathetic dominance
dc.subject.keywordsParasympathetic nervous system
dc.subject.keywordsVascular health
dc.subject.keywordsResting autonomic function
dc.subject.keywordsCorrelation
dc.subject.keywordsLinear regression
dc.subject.keywordsCross sectional
dc.subject.keywordsParasympathetic nerve activation
dc.subject.keywordsSympathetic nerve activation
dc.subject.keywordsReactive oxygen species
dc.subject.keywordsOxidative stress
dc.subject.keywordsInsulin
dc.subject.keywordsAtherogenesis
dc.subject.keywordsVascular lesions
dc.subject.keywordsBrain blood flow
dc.subject.keywordsCerebral blood flow
dc.subject.keywordsVasoconstriction
dc.subject.keywordsMemory
dc.subject.keywordsTemporal lobe
dc.subject.keywordsUltrasound
dc.subject.keywordsSupine
dc.subject.keywordsHypoperfusion
dc.subject.keywordsParasympathetic withdrawal
dc.titleComparison of Autonomic and Cardiovascular Dysfunction to Cognitive Decline in Persons with Type 2 Diabetes
dc.typeElectronic Thesis or Dissertation

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