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The Effect of Acute and Chronic Exercise on Mitochondrial Respiratory Sensitivity to ADP in Human Skeletal Muscle

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dc.contributor.advisorPerry, Christopher G. R.
dc.creatorHughes, Meghan Clare
dc.date.accessioned2015-12-16T19:18:30Z
dc.date.available2015-12-16T19:18:30Z
dc.date.copyright2015-06-26
dc.date.issued2015-12-16
dc.date.updated2015-12-16T19:18:30Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractADP/ATP is believed to either diffuse slowly between mitochondria and the cytosol or be substituted with fast diffusing creatine (Cr) and phosphocreatine (PCr) ‘phosphate shuttling’ catalyzed by mitochondrial creatine kinase. Previous studies assessing Cr-dependent and independent ADP-stimulated respiratory kinetics showed acute exercise had no effect or impairment on ADP/ATP diffusion but promoted phosphate shuttling. Conversely, chronic exercise impaired both models of energy exchange. In an attempt to reconcile these seemingly diverse findings, we employed a longitudinal study design to assess the acute and chronic effects of exercise on energy exchange in human skeletal muscle when modeling in vivo PCr/Cr conditions in vitro. Our findings demonstrate an impairment in energy exchange when modeling in vivo concentrations of PCr/Cr found during high intensity exercise, despite an increase in mitochondrial content. These results contradict classical models of endurance exercise adaptations which hypothesize that greater oxidative capacity coincides with improved energy exchange.
dc.identifier.urihttp://hdl.handle.net/10315/30666
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsvoltage dependent anion channel
dc.subject.keywordsadenine nucleotide translocase
dc.subject.keywordsmitochondrial creatine kinase
dc.subject.keywordsoxidative capacity
dc.titleThe Effect of Acute and Chronic Exercise on Mitochondrial Respiratory Sensitivity to ADP in Human Skeletal Muscle
dc.typeElectronic Thesis or Dissertation

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