Synaptic Plasticity in Murine Autism Spectrum Disorder Models: An Electrophysiological Perspective

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dc.contributor.advisorConnor, Steven
dc.contributor.authorJass, Amanda
dc.date.accessioned2021-11-15T15:22:07Z
dc.date.available2021-11-15T15:22:07Z
dc.date.copyright2021-06
dc.date.issued2021-11-15
dc.date.updated2021-11-15T15:22:07Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractChanges in synaptic strength of small neuronal populations are difficult to observe in the live human brain; however, these alterations are necessary to study in order to better understand the mechanisms that underlie neurodevelopmental disorders, such as autism spectrum disorder (ASD). Through manipulation of genes and environmental toxin exposure implicated in the etiology of ASD, we can generate mouse models suitable for gaining insight into synaptic plasticity abnormalities. In the following report, I explore how to set up electrophysiology equipment for efficient measure of neuronal population responses in the mouse hippocampus. I then characterize synaptic plasticity aberrations in the prostaglandin E2 (PGE2) mouse model of ASD, a developmental toxins model whereby the pregnant mouse is injected with PGE2. The offspring of PGE2-injected mice were found to have diminished baseline synaptic response and enhanced potentiation during the first 10 minutes following single-train, high-frequency stimulus in the CA3-CA1 region of the hippocampus.
dc.identifier.urihttp://hdl.handle.net/10315/38687
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectNeurosciences
dc.subject.keywordsAutism spectrum disorder
dc.subject.keywordsASD
dc.subject.keywordsSynaptic plasticity
dc.subject.keywordsHippocampus
dc.subject.keywordsMouse models
dc.subject.keywordsPGE2
dc.subject.keywordsLong-term potentiation
dc.subject.keywordsElectrophysiology
dc.titleSynaptic Plasticity in Murine Autism Spectrum Disorder Models: An Electrophysiological Perspective
dc.typeElectronic Thesis or Dissertation

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