Characterizing The Role Of Sulforaphane In Mitochondrial Function And Content In Skeletal Muscle Cells

Simple item page
dc.contributor.advisorHood, David
dc.contributor.authorChampsi, Sabrina
dc.date.accessioned2024-11-07T11:08:02Z
dc.date.available2024-11-07T11:08:02Z
dc.date.copyright2024-07-24
dc.date.issued2024-11-07
dc.date.updated2024-11-07T11:08:01Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractA healthy mitochondrial reticulum is critical for the maintenance of skeletal muscle. Preservation of the pre-existing pool through the antioxidant response and synthesis of new mitochondria (biogenesis) ensures the quality and quantity of mitochondria is sustained. Exercise has been established an effective intervention to enhance the mitochondrial phenotype, since it elicits metabolic alterations which drive these quality control processes. To evaluate if a pharmaceutical intervention may be able to mimic or enhance exercise induced-mitochondrial adaptations, the compound sulforaphane (SFN) was examined. SFN has been reported as a potent activator of the nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling cascade which enhances the expression of antioxidant and cytoprotective-related genes. Although activation of this signaling cascade has proven to be beneficial, its relevance to mitochondria has not been fully understood. To investigate this, SFN was combined with an in vitro model of “exercise” and mitochondrial parameters were examined. Our results suggests that SFN activates pathways that elicit exercise-induced mitochondrial adaptations.
dc.identifier.urihttps://hdl.handle.net/10315/42443
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subject.keywordsNrf-2
dc.subject.keywordsMitochondria
dc.subject.keywordsSkeletal Muscle
dc.subject.keywordsC2C12
dc.subject.keywordsROS
dc.subject.keywordsAntioxidants
dc.subject.keywordsExercise
dc.subject.keywordsSulforaphane
dc.subject.keywordsLysosomes
dc.titleCharacterizing The Role Of Sulforaphane In Mitochondrial Function And Content In Skeletal Muscle Cells
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Champsi_Sabrina_2024_MSc.pdf
Size:
34.45 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.39 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.