Elucidating the Role of Syntaxin-1A in Cardiac Excitation-Contraction Coupling and Hypertrophic Remodeling in the Adult Mouse Heart

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dc.contributor.advisorTsushima, Robert G.
dc.contributor.authorAnser, Fahad
dc.date.accessioned2024-03-18T17:59:58Z
dc.date.available2024-03-18T17:59:58Z
dc.date.issued2024-03-16
dc.date.updated2024-03-16T10:47:55Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractSyntaxin-1A (STX1A) is a member of the SNARE family which is recognized for its role in membrane exocytosis and ion-channel regulation. Although the physiological properties of STX1A has been assessed in many tissues, its role within the heart remains unelucidated. To address this, a cardiomyocyte specific STX1A knockout (KO) model was generated in adult C57BL/6J mice. Through utilization of both in vivo and in vitro approaches, STX1A haploinsufficiency was demonstrated to induce transient contractile dysfunction, a global electromechanical delay, and reduction in Ca2+ handling gene expression. The depressed cardiac function was supported by volumetric overload of the left-ventricle and cardiomyocyte/sarcomeric restructuring. Furthermore, pathological hypertrophy was observed as evident by the re-expression of fetal genes and left-ventricular fibrosis. Collectively, the results suggest an important role of STX1A in cardiac E-C coupling, whereby its KO impairs the heart’s electromechanical function and induces ventricular remodelling to compensate for the elevated hemodynamic volume overload.
dc.identifier.urihttps://hdl.handle.net/10315/41887
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectPhysiology
dc.subject.keywordsSNAREs
dc.subject.keywordsSTX1A
dc.subject.keywordsCardiac
dc.subject.keywordsHypertrophy
dc.subject.keywordsHeart failure
dc.titleElucidating the Role of Syntaxin-1A in Cardiac Excitation-Contraction Coupling and Hypertrophic Remodeling in the Adult Mouse Heart
dc.typeElectronic Thesis or Dissertation

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