The Human Dentate Gyrus Plays A Necessary Role in Discriminating New Memories

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dc.contributor.advisorRosenbaum, Shayna
dc.creatorBaker, Stevenson Walkley
dc.date.accessioned2016-11-25T14:12:03Z
dc.date.available2016-11-25T14:12:03Z
dc.date.copyright2016-07-28
dc.date.issued2016-11-25
dc.date.updated2016-11-25T14:12:03Z
dc.degree.disciplinePsychology (Functional Area: Clinical Psychology)
dc.degree.levelMaster's
dc.degree.nameMA - Master of Arts
dc.description.abstractEpisodic memory provides us with the ability to re-experience unique events in rich detail. For this to occur, we must be able to 1) behaviorally pattern separate or discriminate new from old experiences, and 2) pattern complete or reinstate memories from partial cues. I report a rare individual with a specific lesion to the dentate gyrus of his hippocampus who has difficulty distinguishing between studied targets and unstudied lures that are visually similar. In addition, he displays a heightened tendency to recognize studied scenes from degraded pictures. These results provide the first direct evidence in humans that discriminating new memories cannot wholly function without an intact dentate gyrus and that this mnemonic ability is dissociable from, but likely interacts with, completion processes in the CA3 subfield of the hippocampus.
dc.identifier.urihttp://hdl.handle.net/10315/32746
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectClinical psychology
dc.subject.keywordsMemory
dc.subject.keywordsCase study method
dc.subject.keywordsPattern separation
dc.subject.keywordsPattern completion
dc.subject.keywordsHippocampus
dc.subject.keywordsDentate gyrus
dc.subject.keywordsCA3
dc.titleThe Human Dentate Gyrus Plays A Necessary Role in Discriminating New Memories
dc.typeElectronic Thesis or Dissertation

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