• Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System 

  Harpur, Brock; Guarna, Maria Marta; Huxter, Elizabeth; Higo, Heather; Moon, Kyung-Mee; Hoover, Shelley E.; Ibrahim, Abdullah; Melathopoulos, Andony P.; Desai, Suresh; Currie, Robert W.; Pernal, Stephen F.; Foster, Leonard J.; Zayed, Amro (Oxford University Press, 2019)

  Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups. Although we have a relatively detailed ...

• Ten simple rules for writing statistical book reviews 

  Lortie, Christopher J. (PLOS, 2019-01-24)

  Statistical books can provide deep insights into statistics and software. There are, however, many resources available to the practitioner. Book reviews have the capacity to function as a critical mechanism for the learner ...

• A proof of concept application of aptachain: ligand-induced self-assembly of a DNA aptamer 

  Neves, Miguel A. D.; Slavkovic, Sladjana; Reinstein, Oren; Shoara, Aron A.; Johnson, Philip E. (Royal Society of Chemistry, 2019-01-14)

  A challenge for the use of aptamers as biosensors is how to signal the occurrence of their ligand binding event into a signal that can be exploited in a detection scheme. Here, we present the concept of “aptachain” formation, ...

• Glycoprotein Hormone Receptor Knockdown Leads to Reduced Reproductive Success in Male Aedes aegypti 

  Rocco, David A.; Garcia, Ana S.G.; Scudeler, Elton L.; dos Santos, Daniela C.; Nobrega, Rafael H.; Paluzzi, Jean-Paul V. (Frontiers, 2019)

  Glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. The heterodimeric glycoprotein hormone GPA2/GPB5 and its receptor LGR1, constitute a recently ...

• Conservation Genomics of the Declining North American Bumblebee Bombus terricola Reveals Inbreeding and Selection on Immune Genes 

  Kent, Clement F.; Dey, Alivia; Patel, Harshilkumar; Tsvetkov, Nadejda; Tiwari, Tanushree; MacPhail, Victoria J.; Gobeil, Yann; Harpur, Brock A.; Gurtowski, James; Schatz, Michael C.; Colla, Sheila R.; Zayed, Amro (Frontiers Media, 2018-08-10)

  The yellow-banded bumblebee Bombus terricola was common in North America but has recently declined and is now on the IUCN Red List of threatened species. The causes of B. terricola’s decline are not well understood. Our ...

• An adiponectin-S1P axis protects against lipid induced insulin resistance and cardiomyocyte cell death via reduction of oxidative stress 

  Botta, Amy; Liu, Ying; Wannaiampikul, Sivaporn; Tungtrongchitr, Rungsunn; Dadson, Keith; Park, Tae-Sik; Sweeney, Gary (Biomed Central, 2019-02-21)

  Background: Adiponectin exerts several beneficial cardiovascular effects, however their specific molecular mechanisms require additional understanding. This study investigated the mechanisms of adiponectin action in the ...

• Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia 

  Shoukat, Affan; Vilches, Thomas; Moghadas, Seyed M. (Biomed Central, 2018-07-03)

  Background: A number of Zika vaccine platforms are currently being investigated, some of which have entered clinical trials. We sought to evaluate the cost-effectiveness of a potential Zika vaccine candidate under the WHO ...

• Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells 

  Pham, Thuc-Nghi Duc; Ma, Weili; Miller, David; Kazakova, Lidia; Benchimol, Samuel (Springer, 2019-01-08)

  There are conflicting reports on the adverse effects of erythropoietin (EPO) for the management of cancer-associated anemia. The recognition that erythropoietin receptors (EPORs) are expressed outside the erythroid lineage ...

• Anaphase Chromosomes in Crane-Fly Spermatocytes Treated With Taxol (Paclitaxel) Accelerate When Their Kinetochore Microtubules Are Cut: Evidence for Spindle Matrix Involvement With Spindle Forces 

  Forer, Arthur; Sheykhani, Rozhan; Berns, Michael W. (Frontiers, 2018-07-24)

  Various experiments have indicated that anaphase chromosomes continue to move after their kinetochore microtubules are severed. The chromosomes move poleward at an accelerated rate after the microtubules are cut but they ...

• A checklist for choosing between R packages in ecology and evolution 

  Lortie, Christopher; Braun, Jenna; Filazzola, Alex; Miguel, Florencia (Wiley, 2020)

  The open source and free programming language R is a phenomenal mechanism to address a multiplicity of challenges in ecology and evolution. It is also a complex ecosystem because of the diversity of solutions available to ...

• Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila 

  Pearlman, Ronald E.; Nabeel-Shah, Syed; Kanwal, Ashraf; Saettone, Alejandro; Garg, Jyoti; Derynck, Joanna; Lambert, Jean-Philippe; Fillingham, Jeffrey (Springer Nature, 2019)

  Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin. Despite its critical roles in chromatin structure ...

• CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti 

  Sajadi, Farwa; Uyuklu, Ali; Paputsis, Christine; Lajevardi, Aryan; Wahedi, Azizia; Ber, Lindsay Taylor; Matei, Andreea; Paluzzi, Jean-Paul V. (Nature, 2020)

  Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs). Several diuretic hormones are known to ...

• A Turtle Population Study in an Isolated Urban Wetland Complex in Ontario Reveals a Few Surprises 

  Dupuis-Desormeaux, Marc; D'Elia, Vince; Burns, Ryan; White, Brittany; MacDonald, Suzanne E. (CSP, 2019)

  We report on the results of the first mark–recapture survey of freshwater turtles in an isolated urban wetland complex in one of Canada’s fastest growing municipalities. Although we found turtles in every surveyed wetland, ...

• A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation 

  White, K. Andrew; Chaminda, Gunawardene D.; Newburn, Laura R. (Oxford University Press, 2019)

  Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) ...

• Insight into mosquito GnRH-related neuropeptide receptor specificity revealed through analysis of naturally occurring and synthetic analogs of this neuropeptide family 

  Wahedi, Azizia; Gade, Gerd; Paluzzi, Jean-Paul (Frontiers, 2019)

  Adipokinetic hormone (AKH), corazonin (CRZ), and the AKH/CRZ-related peptide (ACP) are neuropeptides considered homologous to the vertebrate gonadotropin-releasing hormone (GnRH). All three Aedes aegypti GnRH-related ...

• The Dimerization Interface in VraR is Essential to Induction of the Cell Wall Stress Response in Staphylococcus aureus: A potential Druggable Target 

  Golemi-Kotra, Dasantila; Tajbakhsh, Ghazal (BMC, 2019)

  Background Staphylococcus aureus remains a medical challenge in the treatment of bacterial infections. It has acquired resistance to commonly used antibiotics, and to those considered to be the last weapons in treating ...

• Smad7:β-catenin Complex Regulates Myogenic Gene Transcription 

  McDermott, John; Tripathi, Soma; Tetsuake, Miyake (Springer Nature, 2019)

  Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling. Here ...

• Shrubs indirectly increase desert seedbanks through facilitation of the plant community 

  Filazzola, Alessandro; Liczner, Amanda Rae; Westphal, Michael; Lortie, Christopher (Public Library of Science, 2019)

  The mechanisms supporting positive ecological interactions are important. Foundation species can structure desert biodiversity by facilitating seedbanks of annual plants, but the direct and indirect mechanisms of shrub ...

• The dark side of facilitation: native shrubs facilitate exotic annuals more strongly than native annuals in net abundance 

  Lucero, Jacob E.; Noble, Taylor; Haas, Stephanie; Westphal, Michael; Butterfield, H. Scott; Lortie, Christopher (Pensoft, 2019-04)

• Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress 

  Sweeney, Gary; Sung, Hye Kyoung; Song, Erfei; Pantopoulos, Kostas; Jahng, James Won Suk (Nature Group, 2019-03)

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