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Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

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Title: Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence
Author: Coderre, Terence J.
Katz, Joel
Vaccarino, Anthony L.
Melzack, Ronald
Abstract: Peripheral tissue damage or nerve injury often leads to pathological pain processes, such as spontaneous pain, hyperalgesia and allodynia, that persist for years or decades after all possible tissue healing has occurred. Although peripheral Neurol mechanisms, such as nociceptor sensitization and neuroma formation, contribute to these pathological pain processes, recent evidence indicates that changes in central Neurol function may also play a significant role. In this review, we examine the clinical and experimental evidence which points to a contribution of central Neurol plasticity to the development of pathological pain. We also assess the physiological, biochemical, cellular and molecular mechanisms that underlie plasticity induced in the central nervous system (CNS) in response to noxious peripheral stimulation. Finally, we examine theories which have been proposed to explain how injury or noxious stimulation lead to alterations in CNS function which influence subsequent pain experience.
Subject: pre-emptive analgesia
pain
neuropathic pain
sensitization
hyperalgesia
plasticity
nociception
Type: Article
Rights: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0K-485H91W-2D-1&_cdi=4865&_user=866177&_pii=030439599390161H&_origin=gateway&_coverDate=03%2F31%2F1993&_sk=999479996&view=c&wchp=dGLzVlb-zSkWA&md5=df7228ec3928380c4d8809b561f654c2&ie=/sdarticle.pdf
http://www.elsevier.com/wps/find/journaldescription.cws_home/506083/description#description
http://www.elsevier.com
URI: http://hdl.handle.net/10315/7929
Published: Elsevier
Citation: Pain, 52(3), 259-285. (1993)
Date: 1993

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