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dc.contributor.authorKelly, K.R.
dc.contributor.authorDeSimone, K
dc.contributor.authorGallie, B.L.
dc.contributor.authorSteeves, J
dc.identifier.citationKelly, K. R., DeSimone, K., Gallie, B. L., & Steeves, J. (2015). Altered brain morphology following long-term survival from early monocular enucleation. Neuroimage: Clinical, 7, 297-305.
dc.description.abstractPurpose Retinoblastoma is typically diagnosed before 5 years of age and is often treated by enucleation (surgical removal) of the cancerous eye. Here, we sought to characterize morphological changes of the cortex following long-term survival from early monocular enucleation. Methods Nine adults with early right-eye enucleation (≤48 months of age) due to retinoblastoma were compared to 18 binocularly intact controls. Surface area, cortical thickness, and gyrification estimates were obtained from T1 weighted images and group differences were examined. Results Early monocular enucleation was associated with increased surface area and/or gyrification in visual (i.e., V1, inferior temporal), auditory (i.e., supramarginal), and multisensory (i.e., superior temporal, inferior parietal, superior parietal) cortices compared with controls. Visual cortex increases were restricted to the right hemisphere contralateral to the remaining eye, consistent with previous subcortical data showing asymmetrical lateral geniculate nucleus volume following early monocular enucleation. Conclusions Altered morphological development of visual, auditory, and multisensory regions occurs subsequent to long-time survival from early eye loss.en_US
dc.publisherNeuroImage: Clinicalen_US
dc.subjectMonocular enucleationen_US
dc.subjectMorphological developmenten_US
dc.subjectEarly visual deprivationen_US
dc.subjectVisual cortexen_US
dc.subjectBrain plasticityen_US
dc.subjectHemisphere asymmetryen_US
dc.titleAltered brain morphology following long-term survival from early monocular enucleation.

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