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Altered White Matter Structure in Adults Following Early Monocular Enucleation

Altered White Matter Structure in Adults Following Early Monocular Enucleation

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Title: Altered White Matter Structure in Adults Following Early Monocular Enucleation
Author: Wong, Nikita Ann
Abstract: Visual deprivation from early monocular enucleation (the surgical removal of one eye) results in a number of long-term behavioural and morphological adaptations in the visual, auditory, and multisensory systems. This thesis aims to investigate how the loss of one eye early in life affects structural connectivity within the brain. A combination of diffusion tensor imaging and tractography was used to examine structural differences in 18 tracts throughout the brain of adult participants who had undergone early monocular enucleation compared to binocularly intact controls. We report significant structural changes to white matter in early monocular enucleation participants that extend beyond the primary visual pathway to include interhemispheric, auditory and multisensory tracts, as well as several long association fibres. Overall these results suggest that early monocular enucleation has long-term effects on white matter structure throughout the brain.
Subject: Neurosciences
Keywords: Monocular enucleation
Diffusion tensor imaging
Structural connectivity
Plasticity
Visual system
Type: Electronic Thesis or Dissertation
Rights: Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
URI: http://hdl.handle.net/10315/34324
Supervisor: Steeves, Jennifer
Degree: MA - Master of Arts
Program: Psychology(Functional Area: Brain, Behaviour & Cognitive Sciences
Exam date: 2017-07-25
Publish on: 2018-03-01

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