A Rapid Derivatization for Quantitation of Perfluorinated Car-boxylic Acids from Aqueous Matrices by Gas Chromatography-Mass Spectrometry
| dc.contributor.author | Ye, RenXi | |
| dc.contributor.author | Di Lorenzo, Robert A. | |
| dc.contributor.author | Clouthier, Jessica | |
| dc.contributor.author | Young, Cora | |
| dc.contributor.author | VandenBoer, Trevor | |
| dc.date.accessioned | 2024-08-26T22:09:00Z | |
| dc.date.available | 2024-08-26T22:09:00Z | |
| dc.date.issued | 2023-05-03 | |
| dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [Journal Title], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.3c00593. | |
| dc.description.abstract | Ultrashort chain perfluorocarboxylic acids (PFCAs) are receiving more attention due to their ever-increasing presence in the environment. Methods have been established for the analysis of short and long-chain PFCAs, while robust quantitation of ultrashort chain species are scarce. Here we develop a novel derivatization method using diphenyl diazomethane for quantitation of C2-C14 PFCAs in aqueous matrices. The method is highlighted by rapid completion of derivatization (<1 min), and retention and separation of ultrashort chain (C2/C3) PFCA derivatives using H2 carrier gas (R > 1.5). A weak anion solid phase extraction procedure for analyte recovery from representative aqueous samples was developed and validated by spike and recovery from ultrapure water, synthetic ocean water, and simulated denuder extracts used for collecting gaseous PFCAs. Recoveries for C2-C9 PFCAs ranged from 83-130 % for the majority of analytes and matrices. The instrument detection limits (IDLs) range from 8-220 fg per injection, and method detection limits (MDLs) range from 0.06-14.6 pg/mL for 500 mL aqueous samples, which are within an order of magnitude to conventional LC-MS/MS methods. The method was applied to the analysis of real samples of tap water, rainwater, ocean water, and annular denuder extracts. The overall method provides a cost-effective alternative to conventional LC-MS/MS methods, overcoming the typical GC-MS drawbacks of high detection limits and long sample preparation times, while being able to simultaneously analyze the complete spectrum of environmentally relevant PFCAs. | |
| dc.description.sponsorship | R. Ye acknowledges funding from York University’s Harold I. Schiff Scholarship and an Ontario Graduate Scholarship. T. C. VandenBoer and C. J. Young acknowledge funding for this work from Discovery Grants awarded by the Natural Sciences and Engineering Research Council of Canada and Grants & Contributions support from Environment and Climate Change Canada. | |
| dc.identifier.citation | Ye, R.; Di Lorenzo, R. A.; Clouthier, J. T.; Young, C. J.; VandenBoer, T. C. A Rapid Derivatization for Quantitation of Perfluorinated Carboxylic Acids from Aqueous Matrices by Gas Chromatography–Mass Spectrometry. Analytical Chemistry (Washington), 2023, 95(19), 7648–7655. | |
| dc.identifier.issn | 1520-6882 | |
| dc.identifier.uri | https://doi.org/10.1021/acs.analchem.3c00593 | |
| dc.identifier.uri | https://hdl.handle.net/10315/42252 | |
| dc.language.iso | en | |
| dc.publisher | ACS Publications | |
| dc.title | A Rapid Derivatization for Quantitation of Perfluorinated Car-boxylic Acids from Aqueous Matrices by Gas Chromatography-Mass Spectrometry | |
| dc.type | Article |