The Relationship Between TOR Activity and the Circadian Clock of Neurospora crassa

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dc.contributor.advisorLakin-Thomas, Patricia
dc.contributor.authorAkhtari, Golnoush
dc.date.accessioned2023-08-04T15:11:37Z
dc.date.available2023-08-04T15:11:37Z
dc.date.issued2023-08-04
dc.date.updated2023-08-04T15:11:36Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractCircadian cycles are 24-hour rhythms that are present in almost all eukaryotes and some prokaryotes. These rhythms are believed to be driven by a Transcription-Translation Feedback Loop (TTFL) including frq, wc-1, and wc-2 genes in our model organism, Neurospora crassa. However, evidence showed that other oscillators (FLO), can drive these rhythms in Neurospora. Our lab previously found mutants in the TOR (Target of Rapamycin) pathway that affect the FLO. Thus, we became interested in the TOR pathway as a potential FLO. I measured 40S ribosomal protein S6 phosphorylation as an assay of TOR activity. I found that TOR activity is rhythmic with a circadian period in the wildtype and is rhythmic with different periods in TOR-mutant and clock-mutant strains. Rhythmic TOR activity correlates with conidiation (spore formation), which is under the control of the clock.
dc.identifier.urihttps://hdl.handle.net/10315/41332
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subject.keywordsCircadian Cycles
dc.subject.keywordsNeurospora crassa
dc.subject.keywordsTOR
dc.subject.keywordsRibosomal Protein S6
dc.titleThe Relationship Between TOR Activity and the Circadian Clock of Neurospora crassa
dc.typeElectronic Thesis or Dissertation

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