Potential Roles Of Circska3 In Epithelial Ovarian Cancer Development

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dc.contributor.advisorChun Peng
dc.contributor.authorAgbede, Oluwatobi Michael
dc.date.accessioned2024-11-07T11:02:13Z
dc.date.available2024-11-07T11:02:13Z
dc.date.copyright2024-05-30
dc.date.issued2024-11-07
dc.date.updated2024-11-07T11:02:12Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractOvarian cancer (OC) is the deadliest gynecologic cancer, of which epithelial ovarian cancer (EOC) is the most prevalent and aggressive form. Circular RNAs (circRNAs) have emerged as potential therapeutic targets and biomarkers in various cancers, including EOC. This study investigated circSKA3, which was identified to be overexpressed in high-grade serous carcinoma (HGSC). Using qRT-PCR, we confirmed upregulation in HGSC tissues compared to less aggressive subtypes. Functional assays revealed circSKA3's tumor-promoting effects in HGSC cell lines, enhancing proliferation, migration, and clonogenicity. We identified its possible involvement in epithelial-mesenchymal transition (EMT) and dysregulation of cellular metabolism, contributing to increased aggressiveness in HGSC. Protein pulldown assays and mass spectrometry analysis also identified potential interacting proteins. We then predicted circSKA3-miRNA-mRNA network to explore potential miRNA-mRNA crosstalk dysregulated by circSKA3. These findings suggest that circSKA3, via a complex regulatory interplay of proteins and miRNA interactions, modulates EMT and cellular metabolism to drive HGSC malignancy.
dc.identifier.urihttps://hdl.handle.net/10315/42403
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectCellular biology
dc.subjectMolecular biology
dc.subject.keywordsOvarian Cancer
dc.subject.keywordsCircular RNA
dc.titlePotential Roles Of Circska3 In Epithelial Ovarian Cancer Development
dc.typeElectronic Thesis or Dissertation

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