Using developing zebrafish (Danio rerio) to examine the effects of exposure to environmentally relevant concentrations of zinc: The implications for assessing zinc contamination in freshwater systems

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dc.contributor.advisorKwong, Raymond W. M.
dc.contributor.advisorNiyogi, Somuya
dc.contributor.authorPuar, Pankaj
dc.date.accessioned2021-11-15T15:34:03Z
dc.date.available2021-11-15T15:34:03Z
dc.date.copyright2021-08
dc.date.issued2021-11-15
dc.date.updated2021-11-15T15:34:03Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractIncreasing concentrations of zinc (Zn) in freshwater aquatic systems around the world have created concern for the many inhabitants of these environments. Zebrafish throughout various developmental stages were exposed to sublethal environmentally relevant concentrations of waterborne and dietary Zn. My research showed that exposures to Zn significantly decreased the survival of the larvae, while also disrupting the homeostasis of several essential trace metals and major ions (i.e., copper, nickel, manganese, calcium). Furthermore, Zn transporters which displayed spatial-specific expression were shown to exhibit complex regulatory patterns dependent on exposure route of Zn and developmental age. Overall, my research showed that developing fish are sensitive to the elevated levels of Zn seen in polluted environments and that future ecological risk management would benefit from incorporating the impacts and parameters assessed in our study (i.e. life stage and exposure route) when developing new environmental guidelines.
dc.identifier.urihttp://hdl.handle.net/10315/38735
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectEnvironmental health
dc.subject.keywordszinc
dc.subject.keywordsZIP
dc.subject.keywordszrt-irt like proteins
dc.subject.keywordszebrafish
dc.subject.keywordsdanio rerio
dc.subject.keywordsmetal regulation
dc.subject.keywordsmanganese
dc.subject.keywordscalcium
dc.subject.keywordsmetal pollution
dc.subject.keywordsfreshwater
dc.subject.keywordsenvironment
dc.subject.keywordsenvironmental contamination
dc.titleUsing developing zebrafish (Danio rerio) to examine the effects of exposure to environmentally relevant concentrations of zinc: The implications for assessing zinc contamination in freshwater systems
dc.typeElectronic Thesis or Dissertation

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