dc.contributor.advisor	Ardern, Chris
dc.contributor.author	Oye-Somefun, Akinkunle Olayemi
dc.date.accessioned	2025-04-10T10:53:54Z
dc.date.available	2025-04-10T10:53:54Z
dc.date.copyright	2024-11-28
dc.date.issued	2025-04-10
dc.date.updated	2025-04-10T10:53:54Z
dc.degree.discipline	Kinesiology & Health Science
dc.degree.level	Doctoral
dc.degree.name	PhD - Doctor of Philosophy
dc.description.abstract	The primary objectives of this dissertation were three-fold: i) to evaluate the association of movement behaviors on incident dementia through a systematic review and meta-analysis; ii) to examine the association of movement behaviors on 3-year changes in memory among middle-aged and older adults, stratified by sex; and iii) to investigate the sex-specific association between movement behaviors on cognitive function changes over three years, including the mediation effects of cardiovascular disease on cognitive function. Data from population-based cohort studies, including the Canadian Longitudinal Study of Aging (CLSA), were utilized. A systematic review and meta-analysis (SRMA), as well as general linear regression, and mediation analyses, were employed. In SRMA Study 1, regular physical activity was associated with a 28% reduction in the risk of incident dementia, while both short (<7 hours) and long (>8 hours) sleep durations were associated with an increased dementia risk (RR = 1.23 and 1.32, respectively). In CLSA Studies 2 and 3, 6-8 hours of sleep was associated with positive changes (z-scores) in immediate and delayed recall among males. Among females, the interaction of higher physical activity levels (≥10 MET-hours weekly) with 8+ hours of sleep and high sedentary time led to an increase in delayed recall. Increasing sedentary time was associated with positive changes in cognitive function in males, while excessive sleep duration was associated with a negative change in cognition. Sitting time was found to mediate the relationship between cardiometabolic components and cognitive changes over three years among males (negatively: systolic blood pressure, high-density lipoprotein, carotid intima-media thickness, glycosylated haemoglobin, and positively: waist circumference, diastolic blood pressure, and triglycerides) but not females. The relationship between sitting time and 3-year change in global cognition was further mediated through waist circumference and high-density lipoprotein among both females and males, while glycosylated hemoglobin mediated the sitting time and cognition relationship among males but not females. This dissertation highlights the importance of optimizing movement behaviors for cognitive health among older adults, emphasizing the opportunity for targeted interventions to reduce dementia risk and enhance overall cognitive functioning.
dc.identifier.uri	https://hdl.handle.net/10315/42844
dc.language	en
dc.rights	Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subject.keywords	Physical activity
dc.subject.keywords	Sleep
dc.subject.keywords	Sedentary behavior
dc.subject.keywords	Dementia
dc.subject.keywords	Cognition
dc.subject.keywords	Memory
dc.subject.keywords	Cardiovascular disease
dc.subject.keywords	Older adults
dc.subject.keywords	Movement behaviours
dc.title	Relationships Between Movement Behaviours And Dementia
dc.type	Electronic Thesis or Dissertation

Relationships Between Movement Behaviours And Dementia

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