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Characterizing the Role of Syntaxin 1A in the Heart

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dc.contributor.advisorTsushima, Robert G.
dc.contributor.authorVirdi, Manvir Singh
dc.date.accessioned2020-05-11T12:48:23Z
dc.date.available2020-05-11T12:48:23Z
dc.date.copyright2019-10
dc.date.issued2020-05-11
dc.date.updated2020-05-11T12:48:23Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe SNARE protein, STX1A, is expressed in various tissues. However, the role of STX1A in the heart remains unclear. Using a cardiac-specific STX1A knockout mouse model, this thesis explores the potential role of STX1A in excitation-contraction coupling. Echocardiography showed STX1A KO mice underwent transient systolic dysfunction persisting for 3 weeks. Ejection fraction and fractional shortening decreased in STX1A KO mice which returned to control levels by the 3rd week. No changes were observed in the control groups. Hypertrophy in STX1A KO hearts was not observed. Invasive hemodynamics revealed no change in LV or aortic pressures. Rate of pressure generation and relaxation were reduced in STX1A KO hearts at 0 weeks. Echocardiography also showed significant delay between the R-wave and onset of contraction in STX1A KO mice when compared to control mice. The observations of this study are indicative of STX1As role in the maintenance of normal excitation-contraction coupling in cardiomyocytes.
dc.identifier.urihttps://hdl.handle.net/10315/37425
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subject.keywordsHeart
dc.subject.keywordsMouse
dc.subject.keywordsExcitation-contraction coupling
dc.subject.keywordsSNARE
dc.subject.keywordsSyntaxin 1A
dc.subject.keywordsSyntaxin 1a heart-specific knockout
dc.subject.keywordsEchocardiography
dc.subject.keywordsHemodynamics
dc.titleCharacterizing the Role of Syntaxin 1A in the Heart
dc.typeElectronic Thesis or Dissertation

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