The B-Catenin Interactome in Myogenic Cells

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dc.contributor.advisorMcDermott, John Charles
dc.contributor.authorFarhat, Fatima
dc.date.accessioned2024-03-18T18:20:37Z
dc.date.available2024-03-18T18:20:37Z
dc.date.issued2024-03-16
dc.date.updated2024-03-16T10:38:17Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractBeta-catenin is a versatile protein implicated in a wide range of cellular processes including cell fate determination, proliferation, differentiation, adhesion, and cell survival. Beta-catenin performs its cellular functions through protein-protein interactions since it lacks the ability to interact directly with DNA. Our group has characterized the beta-catenin protein interactome in myogenic cells using a GFP-Nanotrap based affinity purification approach followed LC-MS/MS analysis which produced a comprehensive list of established and potential beta-catenin interactors. The objective of this study was to investigate the beta-catenin interactome dataset to better understand the molecular mechanisms underlying the function of beta-catenin in myogenic cells. To address this objective, we have used bioinformatic and biochemical approaches directed at identifying one potential beta-catenin binding partner and investigating its effect on beta-catenin’s function.
dc.identifier.urihttps://hdl.handle.net/10315/41972
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subject.keywordsBiology
dc.subject.keywordsProteomic interactome
dc.subject.keywordsGene expression
dc.subject.keywordsMyogenesis
dc.titleThe B-Catenin Interactome in Myogenic Cells
dc.typeElectronic Thesis or Dissertation

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