A Stable Dicationic Salt in Reactive DESI-MS Imaging in Positive Ion Mode to Analyze Biological Samples

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dc.contributor.advisorIfa, Demian R.
dc.creatorLostun, Dragos
dc.date.accessioned2015-12-16T19:15:54Z
dc.date.available2015-12-16T19:15:54Z
dc.date.copyright2015-05-20
dc.date.issued2015-12-16
dc.date.updated2015-12-16T19:15:54Z
dc.degree.disciplineChemistry
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractA dicationic salt was applied for imaging in reactive desorption electrospray ionization mass spectrometry (DESI-MS) on biological samples. The samples interrogated in this experiment were whole body zebrafish tissues and rat brain tissue. The stable dictation salt forms a stable bond with biological tissue fatty acids and lipids and allows detection in positive ion mode. Reactive DESI-MS imaging in positive ion mode of rat brain and zebrafish tissues allowed enhanced detection of certain compounds commonly observed in negative ion mode. Variance in intensity between negative and positive mode indicate that the ionization process could be affected by matrix effects of various tissues, leading to different overall intensity which could provide new information on the same compounds when compared between negative ion mode images and reactive DESI positive ion mode images.
dc.identifier.urihttp://hdl.handle.net/10315/30647
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectChemistry
dc.subjectAnalytical chemistry
dc.subject.keywordsDESI-MS
dc.subject.keywordsChemistry
dc.subject.keywordsdicationic salt
dc.subject.keywordsmass spectrometry
dc.subject.keywordsdesorption electrospray ionization
dc.titleA Stable Dicationic Salt in Reactive DESI-MS Imaging in Positive Ion Mode to Analyze Biological Samples
dc.typeElectronic Thesis or Dissertation

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