A Role for p107 in Muscle Satellite Cell Self-Renewal

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dc.contributor.advisorScime, Anthony
dc.contributor.authorShah, Vicky
dc.date.accessioned2024-03-18T18:20:41Z
dc.date.available2024-03-18T18:20:41Z
dc.date.issued2024-03-16
dc.date.updated2024-03-16T10:38:09Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractIt is well established that skeletal muscle homeostasis is dependent on the activity of the muscle resident stem cells termed satellite cells (SCs). Many neuromuscular dystrophies and complications brought on from ageing are associated with decline to the SC population. Thus, there is a critical need to investigate the control mechanisms that dictate SC fate decisions for self-renewal that are crucial to maintain the SC population. A fundamental regulator of SC fate decisions is mitochondrial metabolism and thereby mitochondrial ATP generation via oxidative phosphorylation (OXPHOS). In our study we uncover a potential novel role for the transcriptional co-repressor retinoblastoma susceptibility protein like 1(Rbl1 or p107) in manipulating the self-renewal capacity of SCs through its mitochondrial localization under the control of the NAD+/NADH ratio. An investigation of this role for p107 function establishes a new mechanism to target SC decline and improve muscle regeneration that is required in muscular dystrophies and ageing.
dc.identifier.urihttps://hdl.handle.net/10315/41973
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectCellular biology
dc.subjectHealth sciences
dc.subject.keywordsMuscle
dc.subject.keywordsStem cell
dc.subject.keywordsSatellite cell
dc.subject.keywordsMuscular dystrophy
dc.subject.keywordsAgeing
dc.subject.keywordsSelf-renewal
dc.subject.keywordsDifferentiation
dc.subject.keywordsMyofiber
dc.titleA Role for p107 in Muscle Satellite Cell Self-Renewal
dc.typeElectronic Thesis or Dissertation

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