The Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control

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dc.contributor.advisorCeddia, Rolando
dc.creatorUthayakumar, Abinas
dc.date.accessioned2015-12-16T19:29:17Z
dc.date.available2015-12-16T19:29:17Z
dc.date.copyright2015-08-26
dc.date.issued2015-12-16
dc.date.updated2015-12-16T19:29:17Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis study investigates the effects of chronic high-fat diet (HFD) and endurance training on Non-Alcoholic Fatty Liver Disease (NAFLD) and glycemic control. Here we report that chronic HFD promotes hepatic steatosis to an extent, which impairs whole body glucose metabolism. Moreover, we illustrate the effectiveness of exercise in attenuating HFD-induced NAFLD. In addition to NAFLD treatment, exercise improves whole body glycemic control and insulin sensitivity. Measures of gluconeogenic markers indicate a reduction in gluconeogenesis (GNG) to be partially attributable to the improved glucose regulation. Importantly, we present the novel finding that chronic endurance exercise reduces the rate of hepatic glycogen synthesis despite improvements in glycemia. Thus, it appears glucose has alternate metabolic fates in the body which forces mobilization rather than storage of glucose in a trained system. Taken together, it appears exercise is an effective therapeutic tool, which can significantly improve the deleterious effects of chronic HF-feeding.
dc.identifier.urihttp://hdl.handle.net/10315/30735
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectKinesiology
dc.subjectPhysiology
dc.subject.keywordsobesity
dc.subject.keywordsexercise
dc.subject.keywordshigh-fat diet
dc.subject.keywordshepatic glucose production
dc.subject.keywordsgluconeogenesis
dc.subject.keywordsglycogen synthesis
dc.subject.keywordshepatic steatosis
dc.subject.keywordsnon-alcoholic fatty liver disease
dc.subject.keywordsinsulin resistance
dc.subject.keywordslipogenesis
dc.subject.keywordsliver
dc.subject.keywordslipid oxidation
dc.subject.keywordschronic endurance training
dc.subject.keywordsglucose 6-phosphate
dc.subject.keywordsglucose
dc.subject.keywordsmetabolism
dc.subject.keywordsglucose tolerance test
dc.subject.keywordspyruvate tolerance test
dc.subject.keywordsinsulin signalling
dc.subject.keywordsdiabetes
dc.subject.keywordsNAFLD
dc.titleThe Effect of High-Fat Diet and Exercise on Non-Alcoholic Fatty Liver Disease and Glycemic Control
dc.typeElectronic Thesis or Dissertation

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