Electrical Pulse Stimulation of MCF7 Breast Cancer Coordinates Autophagy Reprogramming and Proliferative Failure Leading to Cellular Senescence

Simple item page
dc.contributor.advisorConnor, Michael K.
dc.contributor.authorShiell, Mitchell Anthony
dc.date.accessioned2020-05-11T12:49:04Z
dc.date.available2020-05-11T12:49:04Z
dc.date.copyright2019-10
dc.date.issued2020-05-11
dc.date.updated2020-05-11T12:49:04Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe utilization of Electrical Pulse Stimulation (EPS) has been predominantly used to study the physiological, cellular, and molecular responses of excitable cells such as nerve and muscle. Based on previous work on myotubes, non-excitable myoblasts, and non-excitable cancerous rhabdomyosarcoma cells, this study looks into the effects of EPS on breast cancer cells (MCF7s). My aim is to characterize the response of MCF7 cells to EPS and add to a working model of cell cycle arrest, autophagy, and cell death mediated by calcium signaling through cell cycle signaling proteins. This is based on the body of literature detailing the effects of EPS on excitable cell types. Ultimately, by stressing cancer cells with EPS, we can learn more about potential novel modes to induce mechanisms of proliferative failure.
dc.identifier.urihttps://hdl.handle.net/10315/37430
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsElectrical Pulse Stimulation
dc.subject.keywordsElectrical Stimulation
dc.subject.keywordsEPS
dc.subject.keywordsMCF7
dc.subject.keywordsMCF-7
dc.subject.keywordsBreast Cancer
dc.subject.keywordsCancer
dc.subject.keywordsAutophagy
dc.subject.keywordsProteostasis
dc.subject.keywordsProliferative Failure
dc.subject.keywordsCellular Senescence
dc.subject.keywordsCell cycle
dc.subject.keywordsCell cycle control
dc.subject.keywordsCell cycle arrest
dc.subject.keywordsCell cycle exit
dc.subject.keywordsCell cycle regulation
dc.subject.keywordsG2/M
dc.titleElectrical Pulse Stimulation of MCF7 Breast Cancer Coordinates Autophagy Reprogramming and Proliferative Failure Leading to Cellular Senescence
dc.typeElectronic Thesis or Dissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Shiell_Mitchell_A_2019_Masters.pdf
Size:
28.6 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.83 KB
Format:
Plain Text
Description:
Download
No Thumbnail Available
Name:
YorkU_ETDlicense.txt
Size:
3.36 KB
Format:
Plain Text
Description:
Download

Collections

Kinesiology & Health Science

All items in the YorkSpace institutional repository are protected by copyright, with all rights reserved except where explicitly noted.