The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance

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dc.contributor.advisorSweeney, Gary
dc.creatorPrioriello, Michelle
dc.date.accessioned2018-03-01T14:03:07Z
dc.date.available2018-03-01T14:03:07Z
dc.date.copyright2017-08-08
dc.date.issued2018-03-01
dc.date.updated2018-03-01T14:03:07Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractRecent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes. Iron overloaded primary neonatal cardiomyocytes, L6 skeletal muscle myoblasts, and an in vivo mouse model was used to examine adiponectin resistance. Data indicates the induction of adiponectin resistance after iron treatment, and that this may occur by changes in adiponectin signalling proteins via the regulation of FOXO1 transcription factor. A decrease in adiponectin sensitivity was not observed in the iron overload mouse model used here, although this may be dependent on amount and duration of iron overload. Overall, this study sheds light on the complex balance of adiponectin signalling under iron overload conditions in heart and skeletal muscle. The data indicates that iron can induce adiponectin resistance, and thus helps to elucidate the cellular mechanisms via which metabolic syndrome disease complications can occur.
dc.identifier.urihttp://hdl.handle.net/10315/34349
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsIron overload
dc.subject.keywordsAdiponectin
dc.subject.keywordsAdiponectin resistance
dc.subject.keywordsIron
dc.subject.keywordsHeart
dc.subject.keywordsMuscle
dc.subject.keywordsAdiponectin signalling
dc.subject.keywordsAdiponectin regulation
dc.subject.keywordsMechanism
dc.subject.keywordsFOXO1 transcription factor
dc.subject.keywordsFOXO1
dc.subject.keywordsDiabetes
dc.subject.keywordsHeart disease
dc.subject.keywordsHeart failure
dc.subject.keywordsCardiac dysfunction
dc.subject.keywordsGlucose metabolism
dc.titleThe Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance
dc.typeElectronic Thesis or Dissertation

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