Understanding the impact of HIV on mpox transmission in the MSM population: A mathematical modeling study

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dc.contributor.authorOmame, Andrew
dc.contributor.authorHan, Qing
dc.contributor.authorIyaniwura, Sarafa A
dc.contributor.authorEbenezer, Adeniyi
dc.contributor.authorBragazzi, Nicola L
dc.contributor.authorWang, Xiaoying
dc.contributor.authorKong, Jude D
dc.contributor.authorWoldegerima, Woldegebriel A
dc.date.accessioned2025-02-24T23:26:50Z
dc.date.available2025-02-24T23:26:50Z
dc.date.issued2024-05-21
dc.descriptionSource info: IDM-D-24-00079
dc.description.abstractThe recent mpox outbreak (in 2022–2023) has different clinical and epidemiological features compared with previous outbreaks of the disease. During this outbreak, sexual contact was believed to be the primary transmission route of the disease. In addition, the community of men having sex with men (MSM) was disproportionately affected by the outbreak. This population is also disproportionately affected by HIV infection. Given that both diseases can be transmitted sexually, the endemicity of HIV, and the high sexual behavior associated with the MSM community, it is essential to understand the effect of the two diseases spreading simultaneously in an MSM population. Particularly, we aim to understand the potential effects of HIV on an mpox outbreak in the MSM population. We develop a mechanistic mathematical model of HIV and mpox co-infection. Our model incorporates the dynamics of both diseases and considers HIV treatment with anti-retroviral therapy (ART). In addition, we consider a potential scenario where HIV infection increases susceptibility to mpox, and investigate the potential impact of this mechanism on mpox dynamics. Our analysis shows that HIV can facilitate the spread of mpox in an MSM population, and that HIV treatment with ART may not be sufficient to control the spread of mpox in the population. However, we showed that a moderate use of condoms or reduction in sexual contact in the population combined with ART is beneficial in controlling mpox transmission. Based on our analysis, it is evident that effective control of HIV, specifically through substantial ART use, moderate condom compliance, and reduction in sexual contact, is imperative for curtailing the transmission of mpox in an MSM population and mitigating the compounding impact of these intertwined epidemics.
dc.description.sponsorshipThis research is funded by the Canadian Institute for Health Research (CIHR) under the Mpox and other zoonotic threats Team Grant (FRN. 187246). W.A.W acknowledges financial support from the NSERC Discovery Grant (Appl No.: RGPIN-2023-05100). JDK acknowledges support from IDRC (Grant No. 109981). JDK equally acknowledges support from NSERC Discovery Grant (Grant No. RGPIN-2022-04559), NSERC Discovery Launch Supplement (Grant No: DGECR-2022-00454), and New Frontier in Research Fund- Exploratory (Grant No. NFRFE-2021-00879). Portions of this work were performed at the Los Alamos National Laboratory under the auspices of the US Department of Energy contract 89233218CNA000001 and supported by NHS grant R01-OD011095. W.A.W., J.D.K, and N.L.B. acknowledge financial support from the CIHR FRN. 187246.
dc.format.mediumElectronic-eCollection
dc.identifier.citationOmame, A., Han, Q., Iyaniwura, S. A., Ebenezer, A., Bragazzi, N. L., Wang, X., Kong, J. D., & Woldegerima, W. A. (2024). Understanding the impact of HIV on mpox transmission in the MSM population: A mathematical modeling study. Infectious Disease Modelling, 9(4), 1117–1137. https://doi.org/10.1016/j.idm.2024.05.008
dc.identifier.issn2468-2152
dc.identifier.issn2468-0427
dc.identifier.urihttps://doi.org/10.1016/j.idm.2024.05.008
dc.identifier.urihttps://hdl.handle.net/10315/42651
dc.language.isoen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.publisherCC BY-NC-ND
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMedical microbiology
dc.subjectBiomedical and clinical sciences
dc.subjectClinical sciences
dc.subjectHealth disparities
dc.subjectInfectious diseases
dc.subjectSexually transmitted infections
dc.subjectHIV/AIDS
dc.subjectSexual and gender minorities (SGM/LGBT*)
dc.subjectPrevention
dc.subjectInfection
dc.subjectGood Health and Well Being
dc.subjectHIV-mpox co-infection
dc.subjectInfectious disease modeling
dc.subjectInvasion reproduction number
dc.subjectControl reproduction number
dc.subjectSensitivity analysis
dc.subjectMSM
dc.symplectic.issue4
dc.symplectic.journalInfectious Disease Modelling
dc.symplectic.pagination1117-1137
dc.symplectic.subtypeJournal article
dc.symplectic.volume9
dc.titleUnderstanding the impact of HIV on mpox transmission in the MSM population: A mathematical modeling study
dc.typeArticle

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