Ambient Ionization: Surface Analysis of Sexual Assault Evidence and 2-Dimensional Imaging of Whole-Body Zebra Fish (Danio Rerio) Using Desorption Electrospray Ionization

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dc.contributor.advisorIfa, Demian R.
dc.creatorChramow, Alexander
dc.date.accessioned2015-08-28T15:33:28Z
dc.date.available2015-08-28T15:33:28Z
dc.date.copyright2014-12-03
dc.date.issued2015-08-28
dc.date.updated2015-08-28T15:33:28Z
dc.degree.disciplineChemistry
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractDesorption electrospray ionization (DESI) is an ambient surface analysis technique capable of producing 2D and 3D images. The ionization mechanism utilizes a pneumatically assisted sprayer to deposit a charged solvent onto a sample surface. Subsequent impacting primary droplets produce ejecting surface secondary droplets containing desolved analytes, which are then detected by a mass analyzer. This thesis explores two fields of application of DESI, forensics and biological tissue analysis. The former involves the analysis of sexual assault evidence, in the form of condoms, lubricants, and their residues as a potential aid in convicting perpetrators. The latter focuses on investigating the potential use of the zebra fish (Danio rerio) as a model vertebrate organism for future toxicological and biological research. Whole-body 2D images were created, highlighting areas of interest such as, the brain, spinal cord, liver, and body fat.
dc.identifier.urihttp://hdl.handle.net/10315/30057
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectAnalytical chemistry
dc.subject.keywordsChemistry
dc.subject.keywordsAnalytical chemistry
dc.subject.keywordsBioanalytical
dc.subject.keywordsForensic
dc.subject.keywordsForensic chemistry
dc.subject.keywordsAnalysis
dc.subject.keywordsMass spectrometry
dc.subject.keywordsMolecule
dc.subject.keywordsMass
dc.subject.keywordsSpectrum
dc.subject.keywordsAmbient ionization
dc.subject.keywordsAmbient
dc.subject.keywordsDESI
dc.subject.keywordsDESI-MS
dc.subject.keywordsDesorption
dc.subject.keywordsDesorption electrospray
dc.subject.keywordsDesorption electrospray ionization
dc.subject.keywordsIon image
dc.subject.keywordsSurface analysis
dc.subject.keywordsSurface
dc.subject.keywordsSexual assault
dc.subject.keywordsEvidence
dc.subject.keywordsCondom
dc.subject.keywordsCondoms
dc.subject.keywordsFingerprint
dc.subject.keywordsZebra fish
dc.subject.keywordsZebrafish
dc.subject.keywordsDanio rerio
dc.subject.keywordsWhole body
dc.subject.keywordsTwo-dimension
dc.subject.keywordsBile salt
dc.subject.keywordsLipid
dc.subject.keywordsBody fat
dc.subject.keywordsTissue
dc.subject.keywordsModel vertebrate
dc.subject.keywordsMSI
dc.subject.keywordsMass spectrometry imaging
dc.subject.keywordsImaging
dc.subject.keywordsIon intensity
dc.titleAmbient Ionization: Surface Analysis of Sexual Assault Evidence and 2-Dimensional Imaging of Whole-Body Zebra Fish (Danio Rerio) Using Desorption Electrospray Ionization
dc.typeElectronic Thesis or Dissertationen_US

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