Theta-Gamma Coordination Between Anterior Cingulate and Prefrontal Cortex Indexes Correct Attention Shifts

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dc.contributor.advisorWomelsdorf, Thilo
dc.creatorVoloh, Benjamin
dc.date.accessioned2015-12-16T19:18:51Z
dc.date.available2015-12-16T19:18:51Z
dc.date.copyright2015-06-29
dc.date.issued2015-12-16
dc.date.updated2015-12-16T19:18:51Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractAnterior cingulate and prefrontal cortex (ACC/PFC) are believed to coordinate activity to flexibly prioritize the processing of goal-relevant over irrelevant information. This between-area coordination may be realized by common low frequency excitability changes synchronizing segregated high-frequency activations. This coordination hypothesis was tested by recording in macaque ACC/PFC during the covert use of attention cues. There were robust increases of 5-10Hz (theta) to 35-55Hz (gamma) phase-amplitude correlation between ACC and PFC during successful attention shifts but not unsuccessful ones. Cortical sites providing theta phases (1) showed a prominent cue induced phase reset, (2) were more likely in ACC than PFC, and (3) hosted neurons with burst firing events that synchronized to distant gamma activity. These findings suggest that inter-areal theta-gamma correlations could follow mechanistically from a cue-triggered reactivation of rule-memory that synchronizes theta across ACC/PFC.
dc.identifier.urihttp://hdl.handle.net/10315/30667
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectNeurosciences
dc.subject.keywordsmacaque
dc.subject.keywordsanterior cingulate cortex
dc.subject.keywordsprefrontal cortex attention
dc.subject.keywordstheta
dc.subject.keywordsgamma
dc.subject.keywordscross-frequency coupling
dc.subject.keywordsphase-amplitude coupling
dc.subject.keywordstheta-gamma coupling
dc.subject.keywordsburst
dc.titleTheta-Gamma Coordination Between Anterior Cingulate and Prefrontal Cortex Indexes Correct Attention Shifts
dc.typeElectronic Thesis or Dissertation

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