Exploring the time-dependent changes to skeletal muscle macrophage redox homeostasis in Myositis

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dc.contributor.advisorPerry, Christopher
dc.contributor.advisorAbdul-Sater, Ali
dc.contributor.authorThuhan, Arshdeep Kaur
dc.date.accessioned2023-12-08T14:41:53Z
dc.date.available2023-12-08T14:41:53Z
dc.date.issued2023-12-08
dc.date.updated2023-12-08T14:41:52Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMyositis, a rare idiopathic inflammatory myopathy (IIM), is characterized by skeletal muscle wasting and weakness. While autoimmune-mediated, the etiology is largely unknown. The focus of this thesis was to assess a modified version of a model commonly used in the literature, known as experimental autoimmune myositis. We assessed the progression of this model over time in the gastrocnemius and soleus muscles, to explore muscle specific changes in the immune response. Our findings reveal changes to ROS production in muscle macrophages, as well alterations in the expression of inflammatory related genes. However, the modified model, with the absence of pertussis toxin, does not replicate the strong disease phenotype observed in traditional EAM models. This allows us to question the extent to which pertussis toxin induces a myositis phenotype as opposed to systemic inflammation. Ultimately, there is a need to develop a comprehensive model of myositis that accurately mimics the human condition.
dc.identifier.urihttps://hdl.handle.net/10315/41734
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subjectCellular biology
dc.subjectImmunology
dc.titleExploring the time-dependent changes to skeletal muscle macrophage redox homeostasis in Myositis
dc.typeElectronic Thesis or Dissertation

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