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Role of water in radiochromic LiPCDA monomer crystal packing and radiotherapy dose response

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dc.contributor.advisorMermut, Ozzy
dc.contributor.authorKaiyum, Rohith Ahmmed
dc.date.accessioned2021-07-06T12:51:43Z
dc.date.available2021-07-06T12:51:43Z
dc.date.copyright2021-04
dc.date.issued2021-07-06
dc.date.updated2021-07-06T12:51:43Z
dc.degree.disciplinePhysics And Astronomy
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractRadiochromic films comprised of lithium-10,12-pentacosa diynoate (LiPCDA) crystals, a form of diacetylene, have been developed for in vivo real-time dosimetry. The polymerization of LiPCDA results in a change in optical density that is related to the absorbed dose. The dose response of diacetylene monomers is dependent on their packing, determined by the R groups. LiPCDA used in commercial film can have two distinct dose sensitive forms, 635LiPCDA and 674LiPCDA, with peak absorbances occurring at 635 nm and 674 nm, respectively. While the two forms do not differ in their R groups, they have different dosimetric behaviours. The 674LiPCDA achieved through desiccation of 635LiPCDA was 3-fold less sensitive to dose and had ~7-fold higher dynamic range. This indicates that the dosimetric behaviour of radiochromic crystals is primarily dependent on structure, controlled by more than just the chemical composition of individual monomers as water appears to have a role in the packing.
dc.identifier.urihttp://hdl.handle.net/10315/38488
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysics
dc.subject.keywordsAbsorption spectroscopy
dc.subject.keywordsGafChromic EBT-3 radiochromic film
dc.subject.keywordsfilm dosimetry
dc.subject.keywordsLiPCDA
dc.subject.keywordsIn vivo dosimetry
dc.titleRole of water in radiochromic LiPCDA monomer crystal packing and radiotherapy dose response
dc.typeElectronic Thesis or Dissertation

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