Treatment of Type 1 Diabetic Rats with An SGLT2 Inhibitor: Interactions with Exercise and Hypoglycemia
dc.contributor.advisor | Riddell, Michael C. | |
dc.creator | Greenberg, Caylee Anna | |
dc.date.accessioned | 2019-03-05T14:59:01Z | |
dc.date.available | 2019-03-05T14:59:01Z | |
dc.date.copyright | 2018-12-14 | |
dc.date.issued | 2019-03-05 | |
dc.date.updated | 2019-03-05T14:59:01Z | |
dc.degree.discipline | Kinesiology & Health Science | |
dc.degree.level | Master's | |
dc.degree.name | MSc - Master of Science | |
dc.description.abstract | Sodium glucose co-transporter 2 inhibitors (SGLT2i) have begun to show promise as an add-on to insulin therapy in patients with type 1 diabetes (T1D), however the effects of these drugs on plasma glucagon concentrations in T1D are not yet known. We investigated whether 8 days of SGLT2i treatment altered plasma glucagon concentrations in response to voluntary physical activity and insulin-induced hypoglycemia in male and female rats with streptozotocin-induced T1D. SGLT2 inhibition did not alter basal or post-exercise glucagon concentrations and did not affect exercise-associated changes in blood glucose levels. Additionally, SGLT2 inhibition did not affect voluntary running distance. However, in males, SGLT2 inhibition appeared to have suppressed the glucagon response to insulin-induced hypoglycemia (+40.4 48.6 pg/mL vs +22.7 30.8 pg/mL, p=0.02) and decreased the time to taken to reach hypoglycemia (63.8 17.2 min vs 30 13.4 min, p<0.0001). These results have potentially concerning implications for the use of SGLT2i in the treatment of T1D. | |
dc.identifier.uri | http://hdl.handle.net/10315/35907 | |
dc.language.iso | en | |
dc.rights | Author owns copyright, except where explicitly noted. Please contact the author directly with licensing requests. | |
dc.subject | Kinesiology | |
dc.subject.keywords | Type 1 diabetes | |
dc.subject.keywords | SGLT2 | |
dc.subject.keywords | Exercise | |
dc.subject.keywords | Hypoglycemia | |
dc.subject.keywords | Blood glucose | |
dc.subject.keywords | SGLT2 inhibitor | |
dc.subject.keywords | Running wheel | |
dc.subject.keywords | Rodents--Rats | |
dc.subject.keywords | Streptozotocin | |
dc.subject.keywords | stz | |
dc.subject.keywords | Insulin | |
dc.subject.keywords | Glucagon | |
dc.title | Treatment of Type 1 Diabetic Rats with An SGLT2 Inhibitor: Interactions with Exercise and Hypoglycemia | |
dc.type | Electronic Thesis or Dissertation |
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