Roles of Calmodulin and a N-Methyl-D-Aspartate Receptor - Pannexin-1 Signaling Complex in Connexin-36 Plasticity

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dc.contributor.advisorZoidl, Georg R.
dc.contributor.authorSiu, Ryan Chi-Fung
dc.date.accessioned2021-03-08T17:23:03Z
dc.date.available2021-03-08T17:23:03Z
dc.date.copyright2020-11
dc.date.issued2021-03-08
dc.date.updated2021-03-08T17:23:03Z
dc.degree.disciplineBiology
dc.degree.levelDoctoral
dc.degree.namePhD - Doctor of Philosophy
dc.description.abstractThe synergic actions of calcium, calmodulin, and calmodulin kinase II are the central mechanism for synaptic plasticity. Until the last two decades, chemical synapses through N-methyl D-aspartate receptors were thought to be the only synapse that demonstrates plasticity. Our research has shown previously that electrical synapses use CaM/CaMKII interaction in a similar Ca2+-dependent process for plasticity. New evidence suggests that other channels and kinases have modulatory roles in the whole mechanism. This thesis explores the contributions and roles that different kinases, receptors, and channels have on electrical synaptic plasticity. The over-arching hypothesis is that the activation of N-methyl-D-aspartate receptors and pannexin1 channels drives Ca2+ change for physiological signaling of Cx36 plasticity. Here, I introduce a novel modality for CaM electrical synapse regulation and unify the electro-chemical transmission mechanism. I demonstrate that both N-methyl-D-aspartate receptors and pannexin1 channels influence the plasticity at the gap junction nexus. These findings opened up new avenues to expand on mechanisms for synaptic plasticity.
dc.identifier.urihttp://hdl.handle.net/10315/38187
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subject.keywordsConnexin 36
dc.subject.keywordsPannexin 1
dc.subject.keywordsNMDAR
dc.subject.keywordsSrc kinase
dc.subject.keywordsFRET
dc.subject.keywordsArclight
dc.subject.keywordsgapFRAP
dc.subject.keywordsMixed synapse
dc.subject.keywordsPlasticity
dc.subject.keywordsTALEN
dc.subject.keywordsCalmodulin
dc.subject.keywordsCaMKII
dc.titleRoles of Calmodulin and a N-Methyl-D-Aspartate Receptor - Pannexin-1 Signaling Complex in Connexin-36 Plasticity
dc.typeElectronic Thesis or Dissertation

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