The Effects of Daily Exercise Duration on Cardiac Responses and Atrial Fibrillation

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dc.contributor.advisorBackx, Peter
dc.contributor.authorGorman, Renee Ann
dc.date.accessioned2023-12-08T14:35:49Z
dc.date.available2023-12-08T14:35:49Z
dc.date.issued2023-12-08
dc.date.updated2023-12-08T14:35:49Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractAtrial fibrillation (AF) is a supraventricular tachyarrhythmia strongly associated with cardiovascular disease (CVD) and sedentary lifestyles. Despite the abundant benefits of regular exercise, AF incidence for professional endurance athletes is proportionate to CVD patients. To assess exercise dose and AF, we compared the effects of strenuous endurance training on mice by varying daily swim durations (120, 180 and 240 minutes). After receiving the same cumulative work while swimming (estimated from O2 consumption), all exercised groups showed similar elevations (P<0.04) in skeletal muscle mitochondria content and ventricular hypertrophy (P<0.02). By contrast, inducible AF increased (P<0.04) progressively with daily swim dose without markedly affecting atrial refractoriness (P>0.05). Associated with a dose dependency is pronounced (P<0.0001) bradycardia, (P<0.003) hypertrophy, (P<0.0007) fibrosis and (P<0.0001) macrophage accumulation in the atria, that is not observed in the ventricles. Our results demonstrate that prolonging daily swim exercise promotes progressively adverse atrial-specific remodelling leading to increased AF susceptibility.
dc.identifier.urihttps://hdl.handle.net/10315/41691
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectPhysiology
dc.subjectPathology
dc.subject.keywordsAtrial fibrillation
dc.subject.keywordsDaily exercise duration
dc.subject.keywordsEndurance training
dc.subject.keywordsCardiovascular
dc.subject.keywordsArrhythmias
dc.titleThe Effects of Daily Exercise Duration on Cardiac Responses and Atrial Fibrillation
dc.typeElectronic Thesis or Dissertation

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