Sex Differences in Endothelial Cell Angiogenic Capacity

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dc.contributor.advisorHaas, Tara
dc.contributor.authorRezvan, Omid
dc.date.accessioned2020-08-11T12:52:51Z
dc.date.available2020-08-11T12:52:51Z
dc.date.copyright2020-06
dc.date.issued2020-08-11
dc.date.updated2020-08-11T12:52:51Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThere is a sex-specific difference in susceptibility to develop obesity-related disorders. Our labs previous study on high-fat fed mice indicated higher angiogenesis in visceral adipose tissue of female mice, which accompanied preserved metabolic function of adipose tissue and better systemic glucose metabolism. The goal of this study was to determine if there are sex-related differences in endothelial cells (EC) angiogenic capacity that may contribute to higher adipose tissue angiogenesis in females. To achieve this, visceral adipose tissue explants as well as cultured EC of male and female mice were used. Female EC showed higher sprouting success ex-vivo. Furthermore, female EC had higher proliferation in vitro. Protein levels of FoxO1 and phosphorylation of p38 MAPK were higher in females. Inhibition of PFKFB3 decreased proliferation only in males. This project provided evidence for inherent sex-related differences in EC angiogenic capacity that may be related to the higher adipose tissue angiogenesis in females.
dc.identifier.urihttp://hdl.handle.net/10315/37772
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectCellular biology
dc.subject.keywordsEndothelial cells
dc.subject.keywordsSex-related differences
dc.subject.keywordsSexual dimorphism
dc.subject.keywordsAngiogenesis
dc.subject.keywordsAngiogenic capacity of Endothelial cells
dc.subject.keywordsMale female endothelial cells
dc.titleSex Differences in Endothelial Cell Angiogenic Capacity
dc.typeElectronic Thesis or Dissertation

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