The Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia

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dc.contributor.advisorHaas, Tara
dc.contributor.authorDe Ciantis, Matthew John
dc.date.accessioned2020-08-11T12:55:06Z
dc.date.available2020-08-11T12:55:06Z
dc.date.copyright2020-06
dc.date.issued2020-08-11
dc.date.updated2020-08-11T12:55:05Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMuscle regeneration requires inflammation followed by microvascular growth and blood-flow recovery; however, these are impaired in ischemic muscle of peripheral artery disease patients. Endothelial cell (EC)-specific Forkhead Box O (FoxO) 1 and 3 proteins are known to influence vascular growth. My thesis aimed to elucidate their contributions to regeneration of ischemic muscle. I hypothesized that depleting both EC-FoxO1 and 3 (EC-FoxO1,3-knockdown (KD)) would most effectively enhance inflammatory resolution, blood flow recovery, microvascular growth and skeletal muscle regeneration following hind-limb ischemia, compared to EC-FoxO1-knockdown (KD) or EC-FoxO1,3-expressing (Control) mice. My results revealed EC-FoxO1,3-KD mice had enhanced post-ischemic microvascular growth, blood flow recovery, myofiber maturation and fibrosis compared to Control and EC-FoxO1-KD mice. Therefore, EC-FoxO1 and 3 depletion can improve multiple aspects of ischemic muscle recovery; highlighting novel roles of EC-FoxO proteins. Ultimately, my thesis provides insight into a potential therapeutic target for the better management of ischemic muscle outcomes.
dc.identifier.urihttp://hdl.handle.net/10315/37788
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectHealth sciences
dc.subject.keywordsVascular disease
dc.subject.keywordsmuscle regeneration
dc.subject.keywordsblood vessels
dc.subject.keywordsblood flow recovery
dc.subject.keywordsmuscle health
dc.subject.keywordsinflammation
dc.subject.keywordsatherosclerosis
dc.subject.keywordsischemia
dc.subject.keywordsperipheral artery disease
dc.titleThe Role of Endothelial FoxO Proteins in Coordinating Skeletal Muscle Recovery Following Hind Limb Ischemia
dc.typeElectronic Thesis or Dissertation

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