Maternal Fluoride Exposure and Offspring IQ: An Investigation of the Potential Mediating Role of Thyroid Dysfunction in Pregnancy

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dc.contributor.advisorTill, Christine
dc.contributor.authorHall, Meaghan Kathleen
dc.date.accessioned2023-12-08T14:21:26Z
dc.date.available2023-12-08T14:21:26Z
dc.date.issued2023-12-08
dc.date.updated2023-12-08T14:21:25Z
dc.degree.disciplinePsychology(Functional Area: Clinical-Developmental)
dc.degree.levelMaster's
dc.degree.nameMA - Master of Arts
dc.description.abstractObjective: Fluoride exposure has been associated with thyroid dysfunction; however, no studies to date have examined whether fluoride disrupts thyroid function in pregnant women. We evaluated the potential thyroid-disrupting effects of fluoride exposure in pregnancy and tested whether thyroid disruption in pregnancy would mediate the association between maternal fluoride exposure and child IQ in Canadian mother-child dyads. Methods: Maternal thyroid dysfunction was estimated using both categorical measures of thyroid health status (i.e., euthyroid, subclinical, and primary hypothyroid) and continuous measures of thyroid hormone levels (i.e., TSH, FT4, and TT4). Results: We observed a statistically significant association between water fluoride concentration and greater risk of primary hypothyroidism, and between primary hypothyroidism in pregnancy and lower IQ among male offspring. Further, higher urinary fluoride concentration was associated with higher TSH among women pregnant with female, but not male fetuses. Maternal thyroid hormone levels were not associated with offspring IQ. Conclusion: Results suggest that maternal thyroid dysfunction in pregnancy may be one mechanism underlying the association between fluoride exposure in pregnancy and offspring IQ.
dc.identifier.urihttps://hdl.handle.net/10315/41592
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectEnvironmental health
dc.subjectEpidemiology
dc.subjectDevelopmental psychology
dc.subject.keywordsFluoride
dc.subject.keywordsWater fluoride
dc.subject.keywordsThyroid
dc.subject.keywordsThyroid hormones
dc.subject.keywordsThyroid disorders
dc.subject.keywordsThyroid function
dc.subject.keywordsHypothyroidism
dc.subject.keywordsIQ
dc.subject.keywordsFSIQ
dc.subject.keywordsIntelligence
dc.subject.keywordsNeurodevelopment
dc.subject.keywordsChildren
dc.subject.keywordsMothers
dc.subject.keywordsMother-child dyads
dc.subject.keywordsPregnant women
dc.subject.keywordsPregnancy
dc.subject.keywordsDevelopment
dc.subject.keywordsBrain
dc.subject.keywordsBrain development
dc.subject.keywordsNeurotoxicants
dc.subject.keywordsNeurotoxicology
dc.subject.keywordsEnvironmental chemicals
dc.subject.keywordsEndocrine-disrupting chemicals
dc.subject.keywordsNeuropsychology
dc.subject.keywordsMechanism
dc.subject.keywordsSex differences
dc.titleMaternal Fluoride Exposure and Offspring IQ: An Investigation of the Potential Mediating Role of Thyroid Dysfunction in Pregnancy
dc.typeElectronic Thesis or Dissertation

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