Regulation of NLRP3 Inflammasome Activation by TRAF1 in Murine Models of Inflammasome-Driven Disease

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dc.contributor.advisorAbdul Sater, Ali
dc.contributor.authorRaspanti, Jonathan Joseph
dc.date.accessioned2022-12-14T16:17:15Z
dc.date.available2022-12-14T16:17:15Z
dc.date.copyright2021-08-04
dc.date.issued2022-12-14
dc.date.updated2022-12-14T16:17:15Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThe NLRP3 inflammasome is a multimeric protein complex that plays a crucial role in the activation and release of IL-1β. Unpublished in-vitro research from our lab highlights the signalling adaptor protein tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) is an important regulator of the NLRP3 inflammasome. Understanding this regulation in-vivo is important because dysregulation of TRAF1 and the NLRP3 inflammasome is implicated in the pathogenesis of autoinflammatory diseases. To this end, two NLRP3 inflammasome-dependent in-vivo models were employed in wild-type (WT) and TRAF1 deficient (TRAF1-/-) mice. In the MSU-induced peritonitis model, TRAF1-/- mice showed increased recruitment of inflammatory leukocytes, while in the crystal-induced arthritis model, TRAF1-/- exhibited a marked increase in knee joint inflammation and expression of pro-inflammatory genes. Altogether, we demonstrate that TRAF1 plays an important role in controlling inflammasome activation and inflammasome-driven diseases, which provides insights that could lead to improved outcomes of NLRP3 inflammasome-related diseases.
dc.identifier.urihttp://hdl.handle.net/10315/40588
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectImmunology
dc.subjectKinesiology
dc.subject.keywordsInflammasome
dc.subject.keywordsTRAF1
dc.subject.keywordsIL-1ß
dc.subject.keywordsRheumatoid arthritis
dc.subject.keywordsCrystal-induced arthritis
dc.subject.keywordsPeritonitis
dc.subject.keywordsCrystal-induced peritonitis
dc.subject.keywordsAuto immune diseases
dc.subject.keywordsInflammation
dc.titleRegulation of NLRP3 Inflammasome Activation by TRAF1 in Murine Models of Inflammasome-Driven Disease
dc.typeElectronic Thesis or Dissertation

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