Continuous and intermittent theta burst stimulation of primary visual cortex do not modulate resting state functional connectivity: A sham-controlled multi-echo fMRI study

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dc.contributor.authorCohan, Remy
dc.contributor.authorRafique, Sara
dc.contributor.authorStoby, Karlene
dc.contributor.authorGorbet, Diana
dc.contributor.authorSteeves, Jennifer Kate Evelyn
dc.date.accessioned2025-02-06T21:55:00Z
dc.date.available2025-02-06T21:55:00Z
dc.date.issued2023-04-16
dc.description.abstractIntroduction: Theta burst stimulation (TBS) is a type of rTMS protocol which has the advantage of a shorter delivery time over traditional rTMS. When applied to motor cortex, intermittent TBS (iTBS) has been shown to yield excitatory aftereffects, whereas continuous TBS (cTBS) may lead to inhibitory aftereffects, both lasting from minutes to hours. The majority of TBS research has targeted motor, frontal, and parietal regions, and to date very few studies have examined its efficacy at visual areas. We designed a sham-controlled study to investigate the immediate poststimulation and short-term (1 h post-stimulation) effects of iTBS and cTBS to V1. Methods: Using multiecho functional magnetic resonance imaging, we measured the direct and indirect effects of TBS by comparing resting state functional connectivity (FC) before and after stimulation in whole brain networks, and seeds from V1 (stimulation site) and neighboring occipital and parietal visual networks. In addition, we also measured pre- and post-TBS phosphene thresholds (PTs) to examine the modulatory effects of TBS on cortical excitability. Results: We found no changes in FC for iTBS, cTBS or sham stimulation conditions from baseline to poststimulation timepoints. Additionally, cTBS and iTBS had no effect on visual cortical excitability. Conclusions: Our results indicate that unlike our previous low frequency rTMS to V1 study, which resulted in widespread FC changes up to at least 1 h after stimulation, TBS to V1 does not affect FC. Contrary to the studies showing comparable TBS and rTMS aftereffects in motor and frontal regions, our findings suggest that a single session of cTBS or iTBS to V1 at 80% PT using a standard protocol of 600 pulses may not be effective in targeting FC, especially in clinical settings where therapy for pathological networks is the goal.
dc.description.sponsorshipCanada First Research Excellence Fund: Vision Science to Application (VISTA), Grant/Award Number: CFREF-2015-00013; Natural Sciences and Engineering Research Council of Canada (NSERC), Grant/Award Number: 327588; Canada Foundation for Innovation (CFI), Grant/Award Number: 12807
dc.identifier.citationCohan, R., Rafique, S. A., Stoby, K. S., Gorbet, D. J., & Steeves, J. K. E. (2023). Continuous and intermittent theta burst stimulation of primary visual cortex do not modulate resting state functional connectivity: A sham‐controlled multi‐echo fMRI study. Brain and Behavior, 13(5), Article e2989. https://doi.org/10.1002/brb3.2989
dc.identifier.issn2162-3279
dc.identifier.issn2162-3279
dc.identifier.urihttps://doi.org/10.1002/brb3.2989
dc.identifier.urihttps://hdl.handle.net/10315/42624
dc.language.isoen
dc.publisherWiley Periodicals, LLC
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFunctional connectivity
dc.subjectMultiecho fMRI
dc.subjectResting state
dc.subjectTheta burst stimulation (TBS)
dc.subjectTranscranial magnetic stimulation (TMS)
dc.subjectVisual networks
dc.titleContinuous and intermittent theta burst stimulation of primary visual cortex do not modulate resting state functional connectivity: A sham-controlled multi-echo fMRI study
dc.typeArticle

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