Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin

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dc.contributor.advisorSweeney, Gary
dc.creatorRai, Esther Priyanka
dc.date.accessioned2015-08-28T15:21:53Z
dc.date.available2015-08-28T15:21:53Z
dc.date.copyright2014-12-12
dc.date.issued2015-08-28
dc.date.updated2015-08-28T15:21:53Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractObesity is a key factor contributing to the “metabolic syndrome” which increases the risk for type 2 diabetes, cardiovascular disease and liver complications. In obese conditions, lipotoxicity is a serious concern as the accumulation of lipids and lipid-intermediates in non-adipose tissue such as skeletal muscle, heart, liver and pancreas, leads to cellular dysfunction and activation of stress responses. In this study, I have examined how palmitate-induced lipotoxicity, effects the cellular processes ER stress, autophagy and apoptosis, in L6 rat skeletal muscle cells. I have elucidated cross-talk mechanisms between these processes, and have demonstrated that palmitate induces excessive protein accumulation, thereby stimulating ER stress, activation of the UPR and subsequent apoptosis. Autophagy may be recruited as a compensatory mechanism to help the cell cope with the stress of protein overload through its degradative pathway. Additionally, adiponectin may increase autophagic flux, thereby contributing to cytoprotective effects of reducing ER stress and apoptosis.
dc.identifier.urihttp://hdl.handle.net/10315/30004
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subjectCellular biology
dc.subject.keywordsObesity
dc.subject.keywordsDiabetes
dc.subject.keywordsMetabolic syndrome
dc.subject.keywordsLipotoxicity
dc.subject.keywordsAutophagy
dc.subject.keywordsEndoplasmic reticulum stress
dc.subject.keywordsER stress
dc.subject.keywordsApoptosis
dc.subject.keywordsSkeletal muscle
dc.subject.keywordsAdiponectin
dc.subject.keywordsPalmitate
dc.subject.keywordsCross-talk
dc.titleEffect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
dc.typeElectronic Thesis or Dissertationen_US

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