Mapping the Essential Genes in the Pericentromeric Heterochromatin of the Second Chromosome's Left Arm in Drosophila melanogaster

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dc.contributor.advisorHilliker, Arthur J.
dc.contributor.authorYuditskiy, Richard
dc.date.accessioned2022-08-08T15:54:45Z
dc.date.available2022-08-08T15:54:45Z
dc.date.copyright2022-04-14
dc.date.issued2022-08-08
dc.date.updated2022-08-08T15:54:45Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractHeterochromatic regions perform essential roles in model organisms such as Drosophila melanogaster, yet not all have been genetically mapped. The current project focused on identifying and mapping the essential heterochromatic genes found in the lethal region of the left arm of the second chromosome (2Lh) in D. melanogaster, constructing a genetic map in the process. This was achieved by finding fatal mutations in D. melanogaster lines via the candidate gene approach, which compared genomic DNA sequences of potential mutant candidates with the genes control line sequence. To indicate their importance, the mutations found were discussed and their effects on the genes are explained. Six out of the seven essential genes have been located: one which was previously found (light), and five in this project: CG42748, Ir40a, CG17493, Slmap, and Cht10. The seventh and final gene, l(2)40Fe, has been deemed unfindable and is explained more thoroughly later in this paper.
dc.identifier.urihttp://hdl.handle.net/10315/39644
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subject.keywordsGenetics
dc.subject.keywordsFly genetics
dc.subject.keywordsFruit fly
dc.subject.keywordsFruit flies
dc.subject.keywordsDrosophila melanogaster
dc.subject.keywordsDrosophila
dc.subject.keywordsmelanogaster
dc.subject.keywordsHeterochromatin
dc.subject.keywordsChromatin
dc.subject.keywordsSequence
dc.subject.keywordsSequences
dc.subject.keywordsSequencing
dc.subject.keywordsMap
dc.subject.keywordsMapping
dc.subject.keywordsGenetic map
dc.subject.keywordsGenetic mapping
dc.subject.keywordsGene
dc.subject.keywordsGenes
dc.subject.keywordsEssential
dc.subject.keywordsEssential gene
dc.subject.keywordsEssential genes
dc.subject.keywordsMapping essential genes
dc.subject.keywordsVital
dc.subject.keywordsVital genes
dc.subject.keywordsVital gene
dc.subject.keywordsVital loci
dc.subject.keywordsLoci
dc.subject.keywordsLethal gene
dc.subject.keywordsLethal genes
dc.subject.keywordsLethal
dc.subject.keywords2L
dc.subject.keywords2Lh
dc.subject.keywords2Lh lethal region
dc.subject.keywordsLethal region
dc.subject.keywordsIdentify
dc.subject.keywordsIdentify genes
dc.subject.keywordsIdentifying genes
dc.subject.keywordsIdentify gene
dc.subject.keywordsIdentifying gene
dc.subject.keywordsIdentification of vital loci
dc.subject.keywordsFinding genes
dc.subject.keywordsFinding gene
dc.subject.keywordsDetermining gene
dc.subject.keywordsDetermining genes
dc.subject.keywordsMutant sequence
dc.subject.keywordsMutant sequences
dc.subject.keywordsCentromere
dc.subject.keywordsCentromeric
dc.subject.keywordsPericentromeric
dc.subject.keywordsSecond chromosome
dc.subject.keywordsChromosome
dc.subject.keywordsChromosomes
dc.subject.keywordsLeft arm
dc.subject.keywordsLeft arm of second chromosome
dc.subject.keywordsLeft arm of chromosome 2
dc.subject.keywordsEGFP
dc.subject.keywordsEGFP diagnostic
dc.subject.keywordsSlmap
dc.subject.keywordsCG17493
dc.subject.keywordsIr40a
dc.subject.keywordsCG42748
dc.subject.keywordsCht10
dc.subject.keywordslt
dc.titleMapping the Essential Genes in the Pericentromeric Heterochromatin of the Second Chromosome's Left Arm in Drosophila melanogaster
dc.typeElectronic Thesis or Dissertation

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