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Collison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss

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dc.contributor.advisorHopkinson, Alan C
dc.creatorLam, Ka Hang Brian
dc.date.accessioned2018-08-27T16:38:39Z
dc.date.available2018-08-27T16:38:39Z
dc.date.copyright2018-04-04
dc.date.issued2018-08-27
dc.date.updated2018-08-27T16:38:39Z
dc.degree.disciplineChemistry
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractCollision-induced dissociation spectra of protonated peptides [(aminoacid)n + H]+ form, after the loss of water, nominal [bn]+ ions which are dependent on both peptide length and amino acid sequence. Protonated tetraglycine loses water predominantly from the first amide; loss from the second amide is a minor channel. The resultant [b4]+ ions have identical CID spectra, indicating interconversion prior to dissociation. Protonated pentaglycine loses water from the first and second amides in high abundances, and the resulting CID spectra of the [b5]+ ions are different, suggesting that interconversion is no longer the dominant pathway. The [b6]+ ions of hexaglycine, formed from the first three amides are in high abundance and their CID spectra are not identical. The substitution of an alanine or proline for a glycine of tetraglycine generally showed reduced water loss and the [b4]+ ions had different fragmentation pathways than those of the [b4]+ ions of tetraglycine.
dc.identifier.urihttp://hdl.handle.net/10315/34997
dc.language.isoen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectChemistry
dc.subject.keywordsMass spectrometry
dc.subject.keywordsCollision-induced dissociation
dc.subject.keywordsPeptide fragmentation
dc.titleCollison-Induced Dissociation of 4-imidazolone Ions; Isomers of [bn]+ Derived from Peptides After Water Loss
dc.typeElectronic Thesis or Dissertation

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