Comparison of Non-Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction

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dc.contributor.advisorEdgell, Heather
dc.contributor.authorNardone, Massimo
dc.date.accessioned2019-11-22T18:51:12Z
dc.date.available2019-11-22T18:51:12Z
dc.date.copyright2019-07
dc.date.issued2019-11-22
dc.date.updated2019-11-22T18:51:12Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractThis thesis examined whether reactive hyperemia peripheral arterial tonometry (RH-PAT) and flow-mediated dilation (FMD), non-invasive measures of peripheral endothelial function, are associated with coronary microvascular function following multiple pharmacological stimuli in patients with suspected coronary microvascular dysfunction (CMD). Patients with suspected CMD completed peripheral vascular assessments using concurrent RH-PAT and FMD, while coronary microvascular function was measured using the index of microvascular resistance (IMR) and the coronary flow reserve (CFR) during endothelial independent (adenosine), endothelial-dependent (acetylcholine), and sympathetically-mediated (dobutamine) hyperemia. Any abnormality in the IMR and/or CFR during the adenosine and/or acetylcholine trials defined patients with CMD. RH-PAT and FMD were attenuated in patients with CMD (P<0.05). RH-PAT was correlated with the dobutamine IMR and CFR (P<0.05), while FMD was correlated with the adenosine (P<0.05) and acetylcholine IMRs (P<0.05), but not the CFRs. Therefore, this thesis suggests that both RH-PAT and FMD can identify patients with CMD in clinical settings.
dc.identifier.urihttp://hdl.handle.net/10315/36751
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsCoronary microvascular function
dc.subject.keywordsCoronary microvascular resistance
dc.subject.keywordsAdenosine
dc.subject.keywordsAcetylcholine
dc.subject.keywordsDobutamine
dc.titleComparison of Non-Invasive Peripheral Vascular Function to Invasive Measures of Coronary Function in Patients with Suspected Coronary Microvascular Dysfunction
dc.typeElectronic Thesis or Dissertation

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