The Effects of Retinoic Acid, Nicotinamide Riboside and Chronic Contractile Activity on Mitochondrial Biogenesis in Skeletal Muscle Cells

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dc.contributor.advisorHood, David A.
dc.contributor.authorDovijarski, Nemanja
dc.date.accessioned2019-11-22T18:35:04Z
dc.date.available2019-11-22T18:35:04Z
dc.date.copyright2019-04
dc.date.issued2019-11-22
dc.date.updated2019-11-22T18:35:03Z
dc.degree.disciplineKinesiology & Health Science
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractMitochondrial biogenesis is a process by which the cell increases its mitochondrial content, involving nuclear-derived and mitochondrial -derived protein synthesis and assembly. Previous literature has identified retinoic acid as a viable agonist of mitochondrial biogenesis in liver and fat tissue, but whether retinoic acid has this effect on muscle is currently unknown. We decided to investigate the effects of retinoic acid on muscle mitochondrial biogenesis by testing it on muscle cells. We also combined RA isomers with known activators of mitochondrial biogenesis, including the drug Nicotinamide Riboside (NR), as well as a model of contracting muscle cells, in order to observe whether there are any interactions. Our results indicate that RA isomer treatment can induce mitochondrial biogenesis, and when combined with chronic contractile activity, has the potential to be additive or synergistic. This suggests that RA may be a useful supplement to accompany exercise training.
dc.identifier.urihttp://hdl.handle.net/10315/36654
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectPhysiology
dc.subject.keywordsRetinoic Acid
dc.subject.keywordsMuscle Cells
dc.subject.keywordsMuscle Physiology
dc.subject.keywordsNicotinamide Riboside
dc.subject.keywords9-cis retinoic acid
dc.subject.keywordsAll-trans retinoic acid
dc.subject.keywordsMitochondria
dc.subject.keywordsMitochondrial biogenesis
dc.titleThe Effects of Retinoic Acid, Nicotinamide Riboside and Chronic Contractile Activity on Mitochondrial Biogenesis in Skeletal Muscle Cells
dc.typeElectronic Thesis or Dissertation

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