AP-1 Proteins Regulate Autophagy in Skeletal Muscle Progenitor Cells

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dc.contributor.advisorMcDermott, John Charles
dc.contributor.authorEdwards, Tracey Anne
dc.date.accessioned2019-11-22T18:35:38Z
dc.date.available2019-11-22T18:35:38Z
dc.date.copyright2019-04
dc.date.issued2019-11-22
dc.date.updated2019-11-22T18:35:38Z
dc.degree.disciplineBiology
dc.degree.levelMaster's
dc.degree.nameMSc - Master of Science
dc.description.abstractAutophagy has been observed to be a key regulator in myogenesis, maintenance of quiescence in satellite cells (SC) and regenerative capacity of skeletal muscle. Activator protein-1 (AP-1) transcription factors have been proteins of interest in autophagy regulation in various cancers due to the established roles of AP-1 in cellular proliferation, death and survival. However, AP-1 involvement in the regulation autophagy in skeletal muscle progenitor cells has not been extensively assessed. AP-1 protein c-Jun is expressed in paired box gene 7 (Pax7) positive satellite cells. AP-1 proteins c-Jun and JunB regulate autophagy. Changes to c-Jun expression lead to changed autophagosome content in C2C12 cells in both growth conditions and induced autophagy conditions. Additionally, c-Jun knockdown altered autophagosome content in cultures containing Pax7+ and Pax7- cells. AP-1 protein c-Jun appeared to be regulated by mTor. AP-1 proteins act as autophagy regulators dependent on cell type and autophagy induction method.
dc.identifier.urihttp://hdl.handle.net/10315/36658
dc.languageen
dc.rightsAuthor owns copyright, except where explicitly noted. Please contact the author directly with licensing requests.
dc.subjectBiology
dc.subject.keywordsautophagy
dc.subject.keywordsskeletal muscle
dc.subject.keywordsAP-1 protein
dc.titleAP-1 Proteins Regulate Autophagy in Skeletal Muscle Progenitor Cells
dc.typeElectronic Thesis or Dissertation

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